Description
External Links
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Expression
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Biological Properties

Proteome  -  SMDBP000003  ( Q13451 )

Description

  • IDSMDBP000003
  • NamePeptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
  • OrganismHomo sapiens (Human)
  • Gene SymbolFKBP5
  • Gene SynonymsAIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10
  • ChromosomeGRCh38 chr6:35573585-35728583; hg19 chr6:35541362-35696360
  • Gene Sequence
    AGAACAAACTCCTACCTCTGTTTGCAACTAAGAGTTACATCCCCCATGCCAAGACCTTCCGAGGCGTCCCAGAGGGGGAAATTCCTCGCTGCCGGACTGCGCCCACCCTTGAGGACCTCACATTCTCTTTGGGCAGAGCGGAAGCCAGACAGAGACAGGGACTACGAAGCGACAATCCCCAGCCCTGTGT Show more... 
  • Protein Sequence
    MTTDEGAKNNEESPTATVAEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLPKIPSNATLFFEIELLDFKGEDLFEDGGIIRRTKRKGEGYSNPNEGATVEIHLEGRCGGRMFDCRDVAFTV  Show more... 
  • Protein Length457
  • Mass51212.0

Expression

  • Abundance
    Export

    Organism part

    		 Protocol Analysis method Abundance Raw Data Provider
    26.21217
    28.11996
    25.63377
    19.80838
    17.57516
    27.74037
    0.30000
    1.00000

Biological Properties

  • General FunctionImmunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277). {ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:12538866, ECO:0000269|PubMed:28147277}.
  • GO – Biological Processchaperone-mediated protein folding [GO:0061077]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; response to bacterium [GO:0009617]
  • GO – Cellular Componentcytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]
  • GO – Molecular FunctionFK506 binding [GO:0005528]; heat shock protein binding [GO:0031072]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]