Description
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Expression
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Biological Properties

Proteome  -  SMDBP000005  ( Q06278 )

Description

  • IDSMDBP000005
  • NameAldehyde oxidase (EC 1.2.3.1) (Aldehyde oxidase 1) (Azaheterocycle hydroxylase) (EC 1.17.3.-)
  • OrganismHomo sapiens (Human)
  • Gene SymbolAOX1
  • Gene SynonymsAO; AOH1
  • ChromosomeGRCh38 chr2:200585952-200677064; hg19 chr2:201450737-201536218
  • Gene Sequence
    ACTCGGCGGGTCGGTGCCGCCGGGTCCCAGGTGCCCGCTACTTCCCAGAACCTCCGCCTCCCGCTCCGGGCCCTCGAACCAGCGCGGACACCACAATGGACCGGGCGTCCGAGCTGCTCTTCTACGTGAACGGCCGCAAGGTGATAGAAAAAAATGTCGATCCTGAAACAATGCTGTTGCCTTATTTGAG Show more... 
  • Protein Sequence
    MDRASELLFYVNGRKVIEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYNPITKRIRHHPANACLIPICSLYGAAVTTVEGIGSTHTRIHPVQERIAKCHGTQCGFCTPGMVMSIYTLLRNHPEPTLDQLTDALGGNLCRCTGYRPIIDACKTFCKTSGCCQSKENGVCCLDQGINGLPE  Show more... 
  • Protein Length1338
  • Mass147918.0

Expression

  • Abundance
    Export

    Organism part

    		 Protocol Analysis method Abundance Raw Data Provider
    24.78326
    27.21873
    24.35215
    20.79509
    17.64986
    25.97658
    3.00000
    2.30000

Biological Properties

  • General FunctionOxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. {ECO:0000269|PubMed:20444863, ECO:0000269|PubMed:22031625, ECO:0000269|PubMed:22279051, ECO:0000269|PubMed:22522748, ECO:0000269|PubMed:22996261, ECO:0000269|PubMed:23857892, ECO:0000269|PubMed:26322824, ECO:0000269|PubMed:7786031, ECO:0000269|PubMed:9224775}.
  • GO – Biological Processlipid metabolic process [GO:0006629]; xenobiotic metabolic process [GO:0006805]
  • GO – Cellular Componentcytosol [GO:0005829]; extracellular exosome [GO:0070062]
  • GO – Molecular Function2 iron, 2 sulfur cluster binding [GO:0051537]; aldehyde oxidase activity [GO:0004031]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; geranial:oxygen oxidoreductase activity [GO:0102797]; heptaldehyde:oxygen oxidoreductase activity [GO:0102798]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; molybdopterin cofactor binding [GO:0043546]; NAD binding [GO:0051287]; oxidoreductase activity [GO:0016491]; protein homodimerization activity [GO:0042803]