Description
External Links
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Expression
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Biological Properties

Proteome  -  SMDBP000012  ( Q9H9T3 )

Description

  • IDSMDBP000012
  • NameElongator complex protein 3 (hELP3) (EC 2.3.1.-) (tRNA uridine(34) acetyltransferase)
  • OrganismHomo sapiens (Human)
  • Gene SymbolELP3
  • Gene SynonymsKAT9; FLJ10422
  • ChromosomeGRCh38 chr8:28090232-28191153; hg19 chr8:27947749-28048670
  • Gene Sequence
    GAAGCTTCAGGAGACCTATCCTCATCTGTGCAAGGAGGAGTGGCCAACTCTGGAGCCCAGGCTGTTGCTTCCTGGTCTGGTGGTGAATCCTCCATAGTCTGGAGATCTCAGCCCTGCTGAGCTGATGATGCTGACTATAGGAGATGTTATTAAACAACTGATTGAAGCCCACGAGCAGGGGAAAGACATC Show more... 
  • Protein Sequence
    MRQKRKGDLSPAELMMLTIGDVIKQLIEAHEQGKDIDLNKVKTKTAAKYGLSAQPRLVDIIAAVPPQYRKVLMPKLKAKPIRTASGIAVVAVMCKPHRCPHISFTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPFLQTRHRIEQLKQLGHSVDKVEFIVMGGTFMALPEEYRDYFIRNLH  Show more... 
  • Protein Length547
  • Mass62259.0

Expression

  • Abundance
    Export

    Organism part

    		 Protocol Analysis method Abundance Raw Data Provider
    23.62545
    24.75679
    21.84202
    17.56958
    8.06684
    0.30000
    0.70000

Biological Properties

  • General FunctionCatalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29415125). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase (PubMed:29415125). Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:19185337). Required for acetylation of GJA1 in the developing cerebral cortex (By similarity). {ECO:0000250|UniProtKB:D5VRB9, ECO:0000250|UniProtKB:Q9CZX0, ECO:0000269|PubMed:19185337, ECO:0000269|PubMed:29415125}.
  • GO – Biological Processcentral nervous system development [GO:0007417]; neuron migration [GO:0001764]; positive regulation of cell migration [GO:0030335]; regulation of transcription by RNA polymerase II [GO:0006357]; tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation [GO:0002926]; tRNA wobble uridine modification [GO:0002098]
  • GO – Cellular Componentcytoplasm [GO:0005737]; cytosol [GO:0005829]; elongator holoenzyme complex [GO:0033588]; nucleolus [GO:0005730]; nucleus [GO:0005634]
  • GO – Molecular Function4 iron, 4 sulfur cluster binding [GO:0051539]; acetyltransferase activity [GO:0016407]; metal ion binding [GO:0046872]; N-acetyltransferase activity [GO:0008080]; phosphorylase kinase regulator activity [GO:0008607]; tRNA binding [GO:0000049]; tRNA uridine(34) acetyltransferase activity [GO:0106261]