Description
External Links
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Expression
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Biological Properties

Proteome  -  SMDBP000023  ( Q93084 )

Description

  • IDSMDBP000023
  • NameSarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 7.2.2.10) (Calcium pump 3)
  • OrganismHomo sapiens (Human)
  • Gene SymbolATP2A3
  • Gene SynonymsSERCA3
  • ChromosomeGRCh38 chr17:3923869-3964464; hg19 chr17:3827163-3867758
  • Gene Sequence
    ATCCTGGCGCGGGCCGGGGCCGCCGCCGCCACTGCCGTCGGGTAAGGTCCCAGCACGGACATGGCCTCGCGCGGCGCCCGCCCGGGCCCGAGTCCCCCGCGCCCCGCTTTGTAGCCCCCCGGCGGAGAGGCGGCCTCGACGGTGCGGACGGCGCAGACGGCCGGGCGGGCGGCATGGAGGCGGCGCATCT Show more... 
  • Protein Sequence
    MEAAHLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKH  Show more... 
  • Protein Length999
  • Mass109256.0

Expression

  • Abundance
    Export

    Organism part

    		 Protocol Analysis method Abundance Raw Data Provider
    15.70373
    21.40260
    20.60479
    20.77045
    17.63303

Biological Properties

  • General FunctionThis magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO:0000269|PubMed:11956212, ECO:0000269|PubMed:15028735}.
  • GO – Biological Processactivation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium ion transport from cytosol to endoplasmic reticulum [GO:1903515]; cellular calcium ion homeostasis [GO:0006874]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; ion transmembrane transport [GO:0034220]; negative regulation of receptor binding [GO:1900121]; regulation of cardiac conduction [GO:1903779]; transport across blood-brain barrier [GO:0150104]
  • GO – Cellular Componentendoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; nuclear membrane [GO:0031965]; organelle membrane [GO:0031090]; platelet dense tubular network membrane [GO:0031095]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]
  • GO – Molecular FunctionATP binding [GO:0005524]; calcium-dependent ATPase activity [GO:0030899]; calcium ion transmembrane transporter activity [GO:0015085]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; P-type ion transporter activity [GO:0015662]; transmembrane transporter binding [GO:0044325]