Description
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Expression
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Biological Properties

Proteome  -  SMDBP000024  ( P07099 )

Description

  • IDSMDBP000024
  • NameEpoxide hydrolase 1 (EC 3.3.2.9) (Epoxide hydratase) (Microsomal epoxide hydrolase) (mEH)
  • OrganismHomo sapiens (Human)
  • Gene SymbolEPHX1
  • Gene SynonymsEPHX; EPOX; HYL1; MEH
  • ChromosomeGRCh38 chr1:225810074-225845563; hg19 chr1:225997776-226033264
  • Gene Sequence
    GGAGACTGCGCCGGGGCTGCTGAAAACTAGCCGAGGAGAGCCAGGGAGCCGGAGAGATCGCGCGCCTGCCGCCGCCGGAGCCTGCGAGCCGAGACCGAGCCATGTGGCTAGAAATCCTCCTCACTTCAGTGCTGGGCTTTGCCATCTACTGGTTCATCTCCCGGGACAAAGAGGAAACTTTGCCACTTGA Show more... 
  • Protein Sequence
    MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEIHDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKIEGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEVICPSIPGYGF  Show more... 
  • Protein Length455
  • Mass52949.0

Expression

  • Abundance
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    Organism part

    		 Protocol Analysis method Abundance Raw Data Provider
    30.74549
    28.50269
    20.24876
    17.98047

Biological Properties

  • General FunctionBiotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids (PubMed:22798687). Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (PubMed:24958911). {ECO:0000250|UniProtKB:P07687, ECO:0000269|PubMed:22798687, ECO:0000269|PubMed:24958911}.
  • GO – Biological Processarachidonic acid metabolic process [GO:0019369]; aromatic compound catabolic process [GO:0019439]; epoxide metabolic process [GO:0097176]; response to organic cyclic compound [GO:0014070]; response to toxic substance [GO:0009636]; xenobiotic metabolic process [GO:0006805]
  • GO – Cellular Componentendoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]
  • GO – Molecular Functioncis-stilbene-oxide hydrolase activity [GO:0033961]; epoxide hydrolase activity [GO:0004301]