Description
External Links
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Expression
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Biological Properties

Proteome  -  SMDBP000847  ( Q3ZCM7 )

Description

  • IDSMDBP000847
  • NameTubulin beta-8 chain (Tubulin beta 8 class VIII)
  • OrganismHomo sapiens (Human)
  • Gene SymbolTUBB8
  • Gene SynonymsOOMD; OOMD2; bA631M21.2
  • ChromosomeGRCh38 chr10:46437-49504; hg19 chr10:92828-95178
  • Gene Sequence
    ATGAGGGAGATCGTGCTCACGCAGATCGGGCAGTGCGGGAATCAGATCGGCGCCAAGTTCTGGGAGGTGATCTCTGATGAACATGCCATCGACTCCGCTGGCACCTACCACGGGGACAGCCACCTGCAGCTGGAGCGCATCAACGTGTACTACAACGAGGCCAGCGGTGGCAGGTACGTGCCCCGCGCTG Show more... 
  • Protein Sequence
    MREIVLTQIGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVYYNEASGGRYVPRAVLVDLEPGTMDSVRSGPFGQVFRPDNFIFGQCGAGNNWAKGHYTEGAELMESVMDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSKIREEYPDRIINTFSILPSPKVSDTVVEPYNATLSVH  Show more... 
  • Protein Length444
  • Mass49776.0

Expression

  • Abundance
    Export

    Organism part

    		 Protocol Analysis method Abundance Raw Data Provider
    27.15416
    29.67445
    28.15063
    25.40971
    24.23179
    30.31193

Biological Properties

  • General FunctionTubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871). {ECO:0000250, ECO:0000269|PubMed:26789871}.
  • GO – Biological Processmicrotubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; oocyte maturation [GO:0001556]; spindle assembly involved in female meiosis [GO:0007056]
  • GO – Cellular Componentcytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; meiotic spindle [GO:0072687]; microtubule [GO:0005874]
  • GO – Molecular FunctionGTPase activity [GO:0003924]; GTP binding [GO:0005525]; structural constituent of cytoskeleton [GO:0005200]