Description
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Expression
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Biological Properties

Proteome  -  SMDBP001142  ( Q8N5K1 )

Description

  • IDSMDBP001142
  • NameCDGSH iron-sulfur domain-containing protein 2 (Endoplasmic reticulum intermembrane small protein) (MitoNEET-related 1 protein) (Miner1) (Nutrient-deprivation autophagy factor-1) (NAF-1)
  • OrganismHomo sapiens (Human)
  • Gene SymbolCISD2
  • Gene SynonymsERIS; Miner1; NAF-1; WFS2; ZCD2
  • ChromosomeGRCh38 chr4:102868992-102892807; hg19 chr4:103790149-103813964
  • Gene Sequence
    AGTGCCCGCCGGCCGCTTCCGCTCCCGGCGCAGGCGCGGCAGCTTGGCCAGAGCGGAGGGGGCTCGGGAGAGGAGTGGACGCCGCTGGCCAGGATGGTGCTGGAGAGCGTGGCCCGTATCGTGAAGGTGCAGCTCCCTGCATATCTGAAGCGGCTCCCAGTCCCTGAAAGCATTACCGGGTTCGCTAGGC Show more... 
  • Protein Sequence
    MVLESVARIVKVQLPAYLKRLPVPESITGFARLTVSEWLRLLPFLGVLALLGYLAVRPFLPKKKQQKDSLINLKIQKENPKVVNEINIEDLCLTKAAYCRCWRSKTFPACDGSHNKHNELTGDNVGPLILKKKEV
  • Protein Length135
  • Mass15278.0

Expression

  • Abundance
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    Organism part

    		 Protocol Analysis method Abundance Raw Data Provider
    27.52261
    29.52266
    26.19260
    19.05152
    18.74874

Biological Properties

  • General FunctionRegulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy. {ECO:0000269|PubMed:17846994, ECO:0000269|PubMed:20010695}.
  • GO – Biological Processautophagy of mitochondrion [GO:0000422]; multicellular organism aging [GO:0010259]; regulation of autophagy [GO:0010506]
  • GO – Cellular Componentendoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; perinuclear endoplasmic reticulum [GO:0097038]; protein-containing complex [GO:0032991]
  • GO – Molecular Function2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]