Description
External Links
#
Expression
#
Biological Properties

Proteome  -  SMDBP001237  ( P22748 )

Description

  • IDSMDBP001237
  • NameCarbonic anhydrase 4 (EC 4.2.1.1) (Carbonate dehydratase IV) (Carbonic anhydrase IV) (CA-IV)
  • OrganismHomo sapiens (Human)
  • Gene SymbolCA4
  • Gene SynonymsCAIV; Car4; RP17
  • ChromosomeGRCh38 chr17:60149942-60179021; hg19 chr17:58227334-58256382
  • Gene Sequence
    ACCCGCGGCGGCCTCCTCGGTGCGCGACCCCCGGCTCAGAGGACTCTTTGCTGTCCCGCAAGATGCGGATGCTGCTGGCGCTCCTGGCCCTCTCCGCGGCGCGGCCATCGGCCAGTGCAGAGTCACACTGGTGCTACGAGGTTCAAGCCGAGTCCTCCAACTACCCCTGCTTGGTGCCAGTCAAGTGGGG Show more... 
  • Protein Sequence
    MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNI  Show more... 
  • Protein Length312
  • Mass35032.0

Expression

  • Abundance
    Export

    Organism part

    		 Protocol Analysis method Abundance Raw Data Provider
    10.08322
    16.45396
    24.44097
    20.78639
    21.08768
    30.27813
    6.00000
    0.30000

Biological Properties

  • General FunctionReversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid. {ECO:0000269|PubMed:15563508}.
  • GO – Biological Processbicarbonate transport [GO:0015701]; one-carbon metabolic process [GO:0006730]
  • GO – Cellular Componentanchored component of external side of plasma membrane [GO:0031362]; apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]; secretory granule membrane [GO:0030667]; trans-Golgi network [GO:0005802]; transport vesicle membrane [GO:0030658]
  • GO – Molecular Functioncarbonate dehydratase activity [GO:0004089]; hydro-lyase activity [GO:0016836]; zinc ion binding [GO:0008270]