Description
External Links
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Expression
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Biological Properties

Transcriptome  -  SMDBT000002  ( A1CF )

Description

  • IDSMDBT000002
  • Gene SymbolA1CF
  • NameAPOBEC1 complementation factor
  • OrganismHomo sapiens (Human)
  • Gene SynonymsACF; ACF64; ACF65; APOBEC1CF; ASP
  • ChromosomeGRCh38 chr10:50799409-50885675; hg19 chr10:52559169-52645435
  • Gene Sequence
    TTTGATATGACGATTAGAGCATAACCCGAGTGACACGTTGAATTCGCCATAATCAAGGAAACCTTTTCCGGGTGGGGATCTCTGAAATTACTCAGTGAGCAACCCTAATTAACCTGATTTTTTGCTGATAATCACTCTCAATGGAATCAAATCACAAATCCGGGGATGGATTGAGCGGCACTCAGAAGGA  Show more... 

Expression

  • Expression in
    Tissues and Cells
    Export
    Organism part Protocol Normalization Expression Raw Data Provider
    0.26223
    0.07605
    0.02488
    0.44803
    0.03084
    0.00000
    0.81784
    1.22698
    0.83809
    4.21373
    4.11936
    4.07577
    0.00000
    13.96420
    0.03360
    0.40304
    0.34935
    0.42710
    0.34754
    • Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Description

Biological Properties

  • General FunctionEssential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. {ECO:0000269|PubMed:10669759, ECO:0000269|PubMed:10781591, ECO:0000269|PubMed:12881431}.
  • GO – Biological Processcytidine to uridine editing [GO:0016554]; embryo implantation [GO:0007566]; mRNA localization resulting in posttranscriptional regulation of gene expression [GO:0010609]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; protein stabilization [GO:0050821]
  • GO – Cellular Componentapolipoprotein B mRNA editing enzyme complex [GO:0030895]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
  • GO – Molecular FunctionmRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]