Description
External Links
#
Expression
#
Biological Properties

Transcriptome  -  SMDBT000006  ( A4GALT )

Description

  • IDSMDBT000006
  • Gene SymbolA4GALT
  • Namealpha 1,4-galactosyltransferase (P blood group)
  • OrganismHomo sapiens (Human)
  • Gene SynonymsA14GALT; A4GALT1; Gb3S; P(k); P1; P1PK; PK
  • ChromosomeGRCh38 chr22:42692112-42721301; hg19 chr22:43088118-43117307
  • Gene Sequence
    AGCAAATAACTGGAATTCCGCAAACACTGGGGTGATGCAGGCAATGCCCTTAGCACGGTCCCGGCAGGAGGCGGTGGGATCAGGCCGACCCGGGTCCCAGGGGTGACAGCGTCCCTTCTCCACTGCAGAATATCGAGATGGATTTGCAGCCGCTGCAAGTGTGTGGAAGGGCCGTGTTCGTGTTGGCAAA  Show more... 

Expression

  • Expression in
    Tissues and Cells
    Export
    Organism part Protocol Normalization Expression Raw Data Provider
    26.11617
    11.92510
    10.46654
    6.34231
    13.28956
    64.13571
    28.28173
    42.93211
    25.74117
    9.24546
    9.58039
    9.33004
    0.00000
    16.78070
    4.67432
    0.79204
    2.07664
    1.17449
    1.66101
    • Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Description

Biological Properties

  • General FunctionCatalyzes the transfer of galactose from UDP-alpha-D-galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)) (PubMed:10748143). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer (PubMed:10748143). Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes (Probable). Globotriaosylceramide/globoside Gb3Cer in blood and tissue cell membranes is the antigen Pk of blood histogroup P (PubMed:10747952). {ECO:0000269|PubMed:10747952, ECO:0000269|PubMed:10748143, ECO:0000305|PubMed:10748143}.; (Microbial infection) Globotriaosylceramide is one of the cellular ligands for bacterial verotoxins. {ECO:0000269|PubMed:10748143}.
  • GO – Biological Processgloboside biosynthetic process [GO:0001576]; glycosphingolipid biosynthetic process [GO:0006688]; plasma membrane organization [GO:0007009]
  • GO – Cellular Componentintegral component of Golgi membrane [GO:0030173]; membrane [GO:0016020]
  • GO – Molecular Functiongalactosyltransferase activity [GO:0008378]; hexosyltransferase activity [GO:0016758]; lactosylceramide 4-alpha-galactosyltransferase activity [GO:0050512]; toxic substance binding [GO:0015643]