Description
External Links
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Expression
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Biological Properties

Transcriptome  -  SMDBT000015  ( AADAT )

Description

  • IDSMDBT000015
  • Gene SymbolAADAT
  • Nameaminoadipate aminotransferase
  • OrganismHomo sapiens (Human)
  • Gene SynonymsKAT2; KATII; KYAT2
  • ChromosomeGRCh38 chr4:170060222-170090221; hg19 chr4:170981373-171011538
  • Gene Sequence
    AAAATGCACAGTCCCAGTGACTGAGAGGAGGCCAGCGGAGCGCGCGGGAACGAGGGTGGGGCCGCTCCCGGCTGGGCGCAGCTCGGGAGCCCCCTGCAGTGGACCCAAGTCGCCGCCAGATGGTTCCCGAGGATTAGGATCACGGGCACTTCCGGTCCCCTCGTCCTCAACCACTGAAGAAGAAGCTTGA  Show more... 

Expression

  • Expression in
    Tissues and Cells
    Export
    Organism part Protocol Normalization Expression Raw Data Provider
    9.98971
    21.49362
    12.41733
    6.33754
    7.80311
    9.20229
    6.72967
    5.19413
    6.07132
    7.86082
    7.22749
    8.16983
    0.00000
    1.20473
    8.38372
    13.08270
    15.87026
    12.10518
    8.78810
    • Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Description

Biological Properties

  • General FunctionTransaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro). {ECO:0000269|PubMed:18620547}.
  • GO – Biological Process2-oxoglutarate metabolic process [GO:0006103]; alpha-amino acid metabolic process [GO:1901605]; biosynthetic process [GO:0009058]; glutamate metabolic process [GO:0006536]; kynurenine metabolic process [GO:0070189]; L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512]
  • GO – Cellular Componentmitochondrial matrix [GO:0005759]
  • GO – Molecular Function2-aminoadipate transaminase activity [GO:0047536]; kynurenine-oxoglutarate transaminase activity [GO:0016212]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483]