Description
External Links
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Expression
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Biological Properties

Transcriptome  -  SMDBT000162  ( ACO1 )

Description

  • IDSMDBT000162
  • Gene SymbolACO1
  • Nameaconitase 1
  • OrganismHomo sapiens (Human)
  • Gene SynonymsACONS; HEL60; IREB1; IREBP; IREBP1; IRP1
  • ChromosomeGRCh38 chr9:32384643-32454769; hg19 chr9:32384641-32454767
  • Gene Sequence
    GAGGCGGCAGCTGGAACCGCGCAGCGCACGGGAACGCGTCCCGCTGCTTGGGTCAGGTTCGCCGGTCGCGGGAGCCCCGCCGTGCAGTCGGAGGAACACGTGGCCATCAGTAATCATGAGCAACCCATTCGCACACCTTGCTGAGCCATTGGATCCTGTACAACCAGGAAAGAAATTCTTCAATTTGAAT  Show more... 

Expression

  • Expression in
    Tissues and Cells
    Export
    Organism part Protocol Normalization Expression Raw Data Provider
    28.99209
    33.85708
    16.10997
    6.24382
    13.14237
    69.15487
    24.62893
    21.26680
    19.10182
    11.04480
    10.84792
    10.92939
    16.51853
    89.59203
    20.75679
    10.73584
    16.26787
    13.53029
    12.06512
    • Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Description

Biological Properties

  • General FunctionBifunctional iron sensor that switches between 2 activities depending on iron availability (PubMed:1946430, PubMed:1281544, PubMed:8041788). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization (PubMed:1946430, PubMed:1281544, PubMed:8041788, PubMed:23891004). Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed:1946430, PubMed:1281544, PubMed:8041788, PubMed:23891004). {ECO:0000269|PubMed:1281544, ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:23891004, ECO:0000269|PubMed:8041788}.; Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000269|PubMed:1281544, ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:8041788}.
  • GO – Biological Processcellular iron ion homeostasis [GO:0006879]; citrate metabolic process [GO:0006101]; intestinal absorption [GO:0050892]; post-embryonic development [GO:0009791]; regulation of translation [GO:0006417]; response to iron(II) ion [GO:0010040]; tricarboxylic acid cycle [GO:0006099]
  • GO – Cellular Componentcytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]
  • GO – Molecular Function3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; citrate dehydratase activity [GO:0047780]; iron-responsive element binding [GO:0030350]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]