Description
External Links
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Expression
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Biological Properties

Transcriptome  -  SMDBT000833  ( AOX1 )

Description

  • IDSMDBT000833
  • Gene SymbolAOX1
  • Namealdehyde oxidase 1
  • OrganismHomo sapiens (Human)
  • Gene SynonymsAO; AOH1
  • ChromosomeGRCh38 chr2:200585952-200677064; hg19 chr2:201450737-201536218
  • Gene Sequence
    ACTCGGCGGGTCGGTGCCGCCGGGTCCCAGGTGCCCGCTACTTCCCAGAACCTCCGCCTCCCGCTCCGGGCCCTCGAACCAGCGCGGACACCACAATGGACCGGGCGTCCGAGCTGCTCTTCTACGTGAACGGCCGCAAGGTGATAGAAAAAAATGTCGATCCTGAAACAATGCTGTTGCCTTATTTGAG  Show more... 

Expression

  • Expression in
    Tissues and Cells
    Export
    Organism part Protocol Normalization Expression Raw Data Provider
    73.09961
    69.73798
    42.19843
    5.89332
    9.41203
    8.27059
    36.65785
    34.38861
    115.11849
    10.71456
    12.05630
    12.39327
    0.00000
    4.15230
    23.13750
    6.16342
    5.36981
    9.60950
    9.98067
    • Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Description

Biological Properties

  • General FunctionOxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. {ECO:0000269|PubMed:20444863, ECO:0000269|PubMed:22031625, ECO:0000269|PubMed:22279051, ECO:0000269|PubMed:22522748, ECO:0000269|PubMed:22996261, ECO:0000269|PubMed:23857892, ECO:0000269|PubMed:26322824, ECO:0000269|PubMed:7786031, ECO:0000269|PubMed:9224775}.
  • GO – Biological Processlipid metabolic process [GO:0006629]; xenobiotic metabolic process [GO:0006805]
  • GO – Cellular Componentcytosol [GO:0005829]; extracellular exosome [GO:0070062]
  • GO – Molecular Function2 iron, 2 sulfur cluster binding [GO:0051537]; aldehyde oxidase activity [GO:0004031]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; geranial:oxygen oxidoreductase activity [GO:0102797]; heptaldehyde:oxygen oxidoreductase activity [GO:0102798]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; molybdopterin cofactor binding [GO:0043546]; NAD binding [GO:0051287]; oxidoreductase activity [GO:0016491]; protein homodimerization activity [GO:0042803]