Description
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Expression
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Biological Properties
Transcriptome - SMDBT003808 ( COPB2 )
Description
- IDSMDBT003808
- Gene SymbolCOPB2
- Namecoatomer protein complex subunit beta 2
- OrganismHomo sapiens (Human)
- Gene SynonymsMCPH19; betaprime-COP; beta'-COP
- ChromosomeGRCh38 chr3:139355595-139389680; hg19 chr3:139076248-139108522
Expression
- Expression in
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Biological Properties
- General FunctionThe coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.; This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). {ECO:0000250}.
- GO – Biological Processendoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; intra-Golgi vesicle-mediated transport [GO:0006891]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; toxin transport [GO:1901998]
- GO – Cellular ComponentCOPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133]
- GO – Molecular Functionstructural molecule activity [GO:0005198]