Description
External Links
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Expression
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Biological Properties

Transcriptome  -  SMDBT004005  ( CRYAB )

Description

  • IDSMDBT004005
  • Gene SymbolCRYAB
  • Namecrystallin alpha B
  • OrganismHomo sapiens (Human)
  • Gene SynonymsCMD1II; CRYA2; CTPP2; CTRCT16; HEL-S-101; HSPB5; MFM2
  • ChromosomeGRCh38 chr11:111908564-111923740; hg19 chr11:111779288-111794464
  • Gene Sequence
    AGAGAACTTTGTCTACAGAACAGGGAGCACTGAATTTGCTCAGTGAGTACTGGGTATGTGTCACATTGCCAAATCCCGGATCACAAGTCTCCATGAACTGCTGGTGAGCTAGGATAATAAAACCCCTGACATCACCATTCCAGAAGCTTCACAAGACTGCATATATAAGGGGCTGGCTGTAGCTGCAGCT  Show more... 

Expression

  • Expression in
    Tissues and Cells
    Export
    Organism part Protocol Normalization Expression Raw Data Provider
    20.79124
    12.06763
    23.00155
    32.31955
    29.67771
    243.34795
    67.65074
    86.02660
    174.77357
    11.07553
    12.46395
    13.37155
    0.00000
    109.61097
    17.96623
    1.05772
    1.37558
    1.21825
    1.07719
    • Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Description

Biological Properties

  • General FunctionMay contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (By similarity). {ECO:0000250|UniProtKB:P23927}.
  • GO – Biological Processapoptotic process involved in morphogenesis [GO:0060561]; cellular response to gamma radiation [GO:0071480]; lens development in camera-type eye [GO:0002088]; microtubule polymerization or depolymerization [GO:0031109]; multicellular organism aging [GO:0010259]; muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of gene expression [GO:0010629]; negative regulation of intracellular transport [GO:0032387]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of transcription, DNA-templated [GO:0045892]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of cell death [GO:0010941]; response to estradiol [GO:0032355]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; stress-activated MAPK cascade [GO:0051403]; tubulin complex assembly [GO:0007021]
  • GO – Cellular Componentactin filament bundle [GO:0032432]; axon [GO:0030424]; cardiac myofibril [GO:0097512]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; M band [GO:0031430]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; synaptic membrane [GO:0097060]; Z disc [GO:0030018]
  • GO – Molecular Functionamyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; protein-containing complex binding [GO:0044877]; protein homodimerization activity [GO:0042803]; structural constituent of eye lens [GO:0005212]; structural molecule activity [GO:0005198]; unfolded protein binding [GO:0051082]