Description
External Links
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Expression
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Biological Properties

Transcriptome  -  SMDBT004163  ( CTSD )

Description

  • IDSMDBT004163
  • Gene SymbolCTSD
  • Namecathepsin D
  • OrganismHomo sapiens (Human)
  • Gene SynonymsCLN10; CPSD; HEL-S-130P
  • ChromosomeGRCh38 chr11:1752755-1763927; hg19 chr11:1773985-1785157
  • Gene Sequence
    AACTGCGGCGTCATCCCGGCTATAAGCGCACGGCCTCGGCGACCCTCTCCGACCCGGCCGCCGCCGCCATGCAGCCCTCCAGCCTTCTGCCGCTCGCCCTCTGCCTGCTGGCTGCACCCGCCTCCGCGCTCGTCAGGATCCCGCTGCACAAGTTCACGTCCATCCGCCGGACCATGTCGGAGGTTGGGGG  Show more... 

Expression

  • Expression in
    Tissues and Cells
    Export
    Organism part Protocol Normalization Expression Raw Data Provider
    274.33422
    162.53617
    128.60097
    22.24243
    75.51107
    382.72250
    179.02341
    284.65113
    184.99209
    12.46052
    12.51148
    12.58853
    27.31013
    0.47810
    135.18063
    51.84809
    32.37244
    40.60135
    63.92707
    • Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Description

Biological Properties

  • General FunctionAcid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. {ECO:0000269|PubMed:27333034}.
  • GO – Biological Processantigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; lipoprotein catabolic process [GO:0042159]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; proteolysis [GO:0006508]; regulation of establishment of protein localization [GO:0070201]
  • GO – Cellular Componentcollagen-containing extracellular matrix [GO:0062023]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane raft [GO:0045121]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]
  • GO – Molecular Functionaspartic-type endopeptidase activity [GO:0004190]; aspartic-type peptidase activity [GO:0070001]; cysteine-type endopeptidase activity [GO:0004197]; peptidase activity [GO:0008233]