Description
External Links
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Expression
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Biological Properties

Transcriptome  -  SMDBT005346  ( ELP3 )

Description

  • IDSMDBT005346
  • Gene SymbolELP3
  • Nameelongator acetyltransferase complex subunit 3
  • OrganismHomo sapiens (Human)
  • Gene SynonymsKAT9; FLJ10422
  • ChromosomeGRCh38 chr8:28090232-28191153; hg19 chr8:27947749-28048670
  • Gene Sequence
    GAAGCTTCAGGAGACCTATCCTCATCTGTGCAAGGAGGAGTGGCCAACTCTGGAGCCCAGGCTGTTGCTTCCTGGTCTGGTGGTGAATCCTCCATAGTCTGGAGATCTCAGCCCTGCTGAGCTGATGATGCTGACTATAGGAGATGTTATTAAACAACTGATTGAAGCCCACGAGCAGGGGAAAGACATC  Show more... 

Expression

  • Expression in
    Tissues and Cells
    Export
    Organism part Protocol Normalization Expression Raw Data Provider
    34.44968
    41.16833
    30.94784
    5.44595
    11.01631
    27.66818
    23.59514
    26.34562
    25.12161
    10.12324
    10.13195
    10.21626
    0.00000
    50.08457
    18.47394
    14.58497
    12.43072
    14.17826
    18.67510
    • Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Description

Biological Properties

  • General FunctionCatalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29415125). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase (PubMed:29415125). Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:19185337). Required for acetylation of GJA1 in the developing cerebral cortex (By similarity). {ECO:0000250|UniProtKB:D5VRB9, ECO:0000250|UniProtKB:Q9CZX0, ECO:0000269|PubMed:19185337, ECO:0000269|PubMed:29415125}.
  • GO – Biological Processcentral nervous system development [GO:0007417]; neuron migration [GO:0001764]; positive regulation of cell migration [GO:0030335]; regulation of transcription by RNA polymerase II [GO:0006357]; tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation [GO:0002926]; tRNA wobble uridine modification [GO:0002098]
  • GO – Cellular Componentcytoplasm [GO:0005737]; cytosol [GO:0005829]; elongator holoenzyme complex [GO:0033588]; nucleolus [GO:0005730]; nucleus [GO:0005634]
  • GO – Molecular Function4 iron, 4 sulfur cluster binding [GO:0051539]; acetyltransferase activity [GO:0016407]; metal ion binding [GO:0046872]; N-acetyltransferase activity [GO:0008080]; phosphorylase kinase regulator activity [GO:0008607]; tRNA binding [GO:0000049]; tRNA uridine(34) acetyltransferase activity [GO:0106261]