Description
External Links
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Expression
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Biological Properties

Transcriptome  -  SMDBT006290  ( FKBP5 )

Description

  • IDSMDBT006290
  • Gene SymbolFKBP5
  • NameFK506 binding protein 5
  • OrganismHomo sapiens (Human)
  • Gene SynonymsAIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10
  • ChromosomeGRCh38 chr6:35573585-35728583; hg19 chr6:35541362-35696360
  • Gene Sequence
    AGAACAAACTCCTACCTCTGTTTGCAACTAAGAGTTACATCCCCCATGCCAAGACCTTCCGAGGCGTCCCAGAGGGGGAAATTCCTCGCTGCCGGACTGCGCCCACCCTTGAGGACCTCACATTCTCTTTGGGCAGAGCGGAAGCCAGACAGAGACAGGGACTACGAAGCGACAATCCCCAGCCCTGTGT  Show more... 

Expression

  • Expression in
    Tissues and Cells
    Export
    Organism part Protocol Normalization Expression Raw Data Provider
    97.71340
    76.95166
    83.63859
    14.02586
    18.59134
    11.62048
    137.43143
    98.62689
    108.28398
    0.00000
    0.00000
    0.00000
    0.00000
    34.46096
    46.44160
    14.08144
    21.10014
    15.46752
    11.36815
    • Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Description

Biological Properties

  • General FunctionImmunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277). {ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:12538866, ECO:0000269|PubMed:28147277}.
  • GO – Biological Processchaperone-mediated protein folding [GO:0061077]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; response to bacterium [GO:0009617]
  • GO – Cellular Componentcytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]
  • GO – Molecular FunctionFK506 binding [GO:0005528]; heat shock protein binding [GO:0031072]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]