Description
External Links
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Expression
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Biological Properties

Transcriptome  -  SMDBT014550  ( PTGDS )

Description

  • IDSMDBT014550
  • Gene SymbolPTGDS
  • Nameprostaglandin D2 synthase
  • OrganismHomo sapiens (Human)
  • Gene SynonymsL-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2
  • ChromosomeGRCh38 chr9:136977504-136981742; hg19 chr9:139871956-139876194
  • Gene Sequence
    GCTCCTCCTGCACACCTCCCTCGCTCTCCCACACCACTGGCACCAGGCCCCGGACACCCGCTCTGCTGCAGGAGAATGGCTACTCATCACACACTGTGGATGGGACTGGCCCTGCTGGGGGTGCTGGGCGACCTGCAGGCAGCACCGGAGGCCCAGGTCTCCGTGCAGCCCAACTTCCAGCAGGACAAGT  Show more... 

Expression

  • Expression in
    Tissues and Cells
    Export
    Organism part Protocol Normalization Expression Raw Data Provider
    1975.76715
    4247.59883
    1972.29054
    1807.68631
    2822.13192
    14.86458
    3576.34043
    817.14978
    571.57046
    16.16977
    15.24241
    16.36899
    0.00000
    2.40697
    1316.06186
    44.31536
    78.20523
    70.27171
    75.67354
    • Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Organism part Protocol Number of cells Article GEO
    Description

Biological Properties

  • General FunctionCatalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation (PubMed:20667974). Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (PubMed:20667974, PubMed:9475419). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity). {ECO:0000250|UniProtKB:O09114, ECO:0000269|PubMed:20667974, ECO:0000269|PubMed:9475419}.
  • GO – Biological Processcyclooxygenase pathway [GO:0019371]; mast cell degranulation [GO:0043303]; prostaglandin biosynthetic process [GO:0001516]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]
  • GO – Cellular Componentendoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; rough endoplasmic reticulum [GO:0005791]
  • GO – Molecular Functionfatty acid binding [GO:0005504]; prostaglandin-D synthase activity [GO:0004667]; retinoid binding [GO:0005501]; small molecule binding [GO:0036094]