Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Aphonia
ADR ID BADD_A00294
ADR Hierarchy
17      Nervous system disorders
17.02      Neurological disorders NEC
17.02.08      Speech and language abnormalities
17.02.08.009      Aphonia
19      Psychiatric disorders
19.19      Communication disorders and disturbances
19.19.01      Communications disorders
19.19.01.002      Aphonia
22      Respiratory, thoracic and mediastinal disorders
22.12      Respiratory tract signs and symptoms
22.12.03      Upper respiratory tract signs and symptoms
22.12.03.001      Aphonia
Description A disorder characterized by the inability to speak. It may result from injuries to the vocal cords or may be functional (psychogenic). [CTCAE] Complete loss of phonation due to organic disease of the larynx or to nonorganic (i.e., psychogenic) causes. [MeSH]
MedDRA Code 10002953
MeSH ID D001044
ADR Severity Grade (FAERS) Not Available
ADR Severity Grade (CTCAE)
Synonym
Aphonia | Loss of voice | Voicelessness | Absence of Voice | Voice Absence | Voice Absences | Functional Aphonia | Aphonia, Functional | Aphonias, Functional | Functional Aphonias | Nonorganic Aphonia | Aphonia, Nonorganic | Aphonias, Nonorganic | Nonorganic Aphonias | Spastic Aphonia | Aphonia, Spastic | Aphonias, Spastic | Spastic Aphonias | Aphonia Paralytica | Paralytica, Aphonia
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01633Oxaliplatin0.000694%
BADD_D01654Palbociclib0.001880%
BADD_D01687Pazopanib0.000739%
BADD_D01835Pregabalin0.000861%
BADD_D01922Regorafenib0.001847%
BADD_D01971Rosuvastatin0.000017%
BADD_D01978Ruxolitinib0.000302%
BADD_D02018Sildenafil0.000548%
BADD_D02047Sodium oxybate0.006518%
BADD_D02058Sorafenib0.000828%
BADD_D02100Sunitinib0.000168%
BADD_D02165Teriflunomide0.002411%
BADD_D02232Tobramycin0.002510%
BADD_D02236Tofacitinib0.012586%
BADD_D02331Valsartan0.000079%
BADD_D02337Varenicline0.001421%
BADD_D02344Vemurafenib0.000302%
BADD_D02346Venlafaxine--
BADD_D02392Zoledronic acid--
BADD_D02407Upadacitinib--
BADD_D02412Octreotide--
BADD_D02416Ropivacaine0.000179%
BADD_D02428Loperamide--
BADD_D02443Tiotropium0.000224%
BADD_D02445Solifenacin0.000174%
BADD_D02464Fingolimod0.001712%
BADD_D02470Nintedanib--
BADD_D02490Apalutamide0.000734%
BADD_D02509Brigatinib0.000246%
BADD_D02524Ivosidenib0.000381%
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