The ADR records are normally indicated in variety of conditions
like physical findings, patient complaints, safety reports and
laboratory results, which are often described in different
strings. Therefore, it is hard to evaluate these medical terms
straightforwardly before standardization. ADReCS adopted MedDRA
and UMLS as major references for ADR term standardization and
the detailed protocol
of ADR standardization is downloadable.
About
Quicksearch
Quick Search allows user to type partial
or full keywords of ADR term, ADReCS ID, MedDRA code, MeSH ID, drug name, drug ID of BADD, ATC code, DrugBank ID, KEGG ID, PubChem ID, CAS RN or molecular formula to
search database. An accurate or detailed keyworks will prompt
the search and narrow down the hits. Keyword combination or
wide characters like "*, +" are not supported.
Step 1: Select "For Drug" if you want to
search drug, or select "For ADR" if you want to
search ADR. Default value is "For ADR".
Step 2: Enter the keyword you want to search, eg.
"Anxiety". You can choose "Fuzzy Search"
or "Accurate Search" to extend the number of result
or get the accurate result.
Step 3: Click the "QuickSearch" button to initiate
search.
Step 4: Initiated search will lead you to the
"Query Result" page, all corresponding result will
be listed, and clicking on the certain ADR term will lead you
to the information page.
About ADR Similarity Search
ADR-based drug similarity is assessed by calculating Tanimoto coefficient between drug-drug pairs by ADRs.
Step 1: Enter or upload a list of ADR IDs or ADR terms you want to search, separated by comma, semicolon, space or newline-delimited.
Step 2: Click the "Search" button to initiate search.
Step 3: The ADR terms and the top 20 most similar drugs will be listed and
sorted by Tanimoto coefficient.
About Structure Similarity Search
Drug structure similarity is assessed by calculating Tanimoto coefficient
between drug-drug pairs by fingerprints.
Step 1: Draw the structure or uploadan SDF or MOL file containing the structure you want to search.
Step 2: Click the "Search" button to initiate search.
Step 3: The top 20 most similar drugs will be listed and
sorted by Tanimoto coefficient.
About ADR Frequency (FAERS)
ADR Frequency of per drug is assessed by adverse event reports information from the FAERS.
About ADR Severity Grade (FAERS)
There are five levels of ADR severity evaluated with enormous reports of adverse events from FAERS, including Mild, Moderate, Severe, Life-threatening or Death.
Five severity grades are shown in five colors vividly.
ADRs were pre-assigned into five severity categories of mild, moderate, severe, life threatening or death according to the Common Terminology Criteria for Adverse Events (CTCAE) v5.0. The CTCAE is a predominant system for describing the severity of adverse events (AEs) commonly encountered in clinical trials.
Five severity grades are shown in five colors vividly.
