Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Cervical dysplasia
ADR ID BADD_A00862
ADR Hierarchy
21      Reproductive system and breast disorders
21.06      Cervix disorders (excl infections and inflammations)
21.06.01      Cervix disorders NEC
21.06.01.002      Cervical dysplasia
Description A malignancy arising in uterine cervical epithelium and confined thereto, representing a continuum of histological changes ranging from well-differentiated CIN 1 (formerly, mild dysplasia) to severe dysplasia/carcinoma in situ, CIN 3. The lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive epidermoid carcinoma, a tendency that is enhanced by concomitant human papillomaviral infection. (Segen, Dictionary of Modern Medicine, 1992) [MeSH]
MedDRA Code 10008263
MeSH ID D018290; D065309
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Cervical dyskaryosis | Cervical dysplasia | Cervical smear pos class III to V | Cervical smear positive class (3-5) | Dysplasia of cervix (uteri) | Koilocytotic pap smear | Cervical intraepithelial neoplasia I | Cervical intraepithelial neoplasia II | Cervical intraepithelial neoplasia III | Cervical intraepithelial neoplasia NOS | Cervical intraepithelial neoplasia | Atypical squamous cells of undetermined significance | Atypical squamous cells, cannot exclude HSIL | Low grade squamous intraepithelial lesion | High grade squamous intraepithelial lesion | ASC-US | ASC-H | LSIL | HSIL | Papanicolaou smear unspecifiable, class II W | Papanicolaou smear abnormal, class III | Papanicolaou smear abnormal, class III D | Cervical high grade squamous intraepithelial lesion | Cervical low grade squamous intraepithelial lesion | Koilocytotic atypia | Koilocytosis | Dysplasia cervical recurrent | AGUS | Atypical glandular cells of undetermined significance | Precancerous lesion of cervix | Cervical Intraepithelial Neoplasia | Neoplasia, Cervical Intraepithelial | Cervical Intraepithelial Neoplasms | Cervical Intraepithelial Neoplasm | Intraepithelial Neoplasm, Cervical | Intraepithelial Neoplasms, Cervical | Neoplasm, Cervical Intraepithelial | Neoplasms, Cervical Intraepithelial | Intraepithelial Neoplasia, Cervical | Cervical Intraepithelial Neoplasia, Grade III
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00066Alendronic acid0.000066%
BADD_D00195Azathioprine0.001097%
BADD_D00479Cladribine0.000306%
BADD_D00499Clomipramine--
BADD_D00500Clomipramine hydrochloride--
BADD_D00529Copper-
BADD_D00574Dalfampridine0.001830%
BADD_D00680Dimethyl fumarate0.002480%
BADD_D00794Ergocalciferol0.001846%
BADD_D01020Glatiramer--
BADD_D01021Glatiramer acetate--
BADD_D01213Isotretinoin0.000386%
BADD_D01250Lasofoxifene--
BADD_D01281Levonorgestrel0.032622%
BADD_D01366Medroxyprogesterone acetate--
BADD_D01617Ondansetron0.000021%
BADD_D01831Prednisolone0.000077%
BADD_D01834Prednisone0.000009%
BADD_D02105Tacrolimus0.000446%
BADD_D02165Teriflunomide0.000362%
BADD_D02213Tibolone--
BADD_D02325Valdecoxib--
BADD_D02464Fingolimod0.006317%
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