Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Congenital central nervous system anomaly
ADR ID BADD_A01021
ADR Hierarchy
03      Congenital, familial and genetic disorders
03.10      Neurological disorders congenital
03.10.02      Central nervous system disorders congenital NEC
03.10.02.004      Congenital central nervous system anomaly
17      Nervous system disorders
17.19      Congenital and peripartum neurological conditions
17.19.01      Congenital and hereditary central nervous system disorders NEC
17.19.01.003      Congenital central nervous system anomaly
Description Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41) [MeSH]
MedDRA Code 10010411
MeSH ID D009436; D061085
ADR Severity Grade (FAERS) Not Available
ADR Severity Grade (CTCAE) Not Available
Synonym
Anomaly congenital central nervous system | Anomaly congenital central nervous system (NOS) | Central nervous system malformation in fetus affecting management of mother | Central nervous system malformation in fetus, antepartum | Central nervous system malformation in fetus, unspecified as to episode of care in pregnancy | Central nervous system malformation in fetus, with delivery | CNS congenital anomaly | Congenital brain anomaly NOS | Congenital central nervous system anomaly | Congenital CNS anomaly NOS | Congenital reduction deformities of brain | Exencephaly | Other congenital anomalies of nervous system | Other specified congenital anomalies of brain | Other specified congenital anomalies of nervous system | Unspecified congenital anomaly of brain, spinal cord, and nervous system | Congenital cerebral anomaly NOS | Corpus callosum agenesis | Neural Tube Defects | Defect, Neural Tube | Defects, Neural Tube | Neural Tube Defect | Developmental Neural Tube Defects | Neural Tube Developmental Defects | Developmental Defects, Neural Tube | Craniorachischisis | Craniorachischises | Diastematomyelia | Diastematomyelias | Tethered Cord Syndrome | Tethered Cord Syndromes | Occult Spinal Dysraphism Sequence | Tethered Spinal Cord Syndrome | Occult Spinal Dysraphism | Dysraphism, Occult Spinal | Dysraphisms, Occult Spinal | Occult Spinal Dysraphisms | Spinal Dysraphism, Occult | Spinal Dysraphisms, Occult | Iniencephaly | Iniencephalies | Neurenteric Cyst | Cyst, Neurenteric | Cysts, Neurenteric | Neurenteric Cysts | Neuroenteric Cyst | Cyst, Neuroenteric | Cysts, Neuroenteric | Neuroenteric Cysts | Spinal Cord Myelodysplasia | Myelodysplasia, Spinal Cord | Myelodysplasias, Spinal Cord | Spinal Cord Myelodysplasias | Acrania | Acranias | Exencephalies
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00497Clomiphene--
BADD_D01142Imiquimod--
BADD_D01942Riluzole--
BADD_D01951Risperidone--
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