Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Constipation
ADR ID BADD_A01059
ADR Hierarchy
07      Gastrointestinal disorders
07.02      Gastrointestinal motility and defaecation conditions
07.02.02      Gastrointestinal atonic and hypomotility disorders NEC
07.02.02.001      Constipation
Description A disorder characterized by irregular and infrequent or difficult evacuation of the bowels. [CTCAE] Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections. | Difficult defecation. | Symptom characterized by the passage of stool once a week or less. [MeSH]
MedDRA Code 10010774
MeSH ID D003248
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Constipation | Constipation (excl faecal impaction) | Iatrogenic constipation | Obstipation | Constipation aggravated | Constipation (excl fecal impaction) | Stools absent | Constipation chronic | Opioid induced constipation | Slow transit constipation | Chronic idiopathic constipation | Absent bowel movement | Habitual constipation | Dyschezia | Colonic Inertia
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02393Zolmitriptan--
BADD_D02394Zolpidem--
BADD_D02395Zolpidem tartrate--
BADD_D02396Zonisamide--
BADD_D02397Zopiclone--
BADD_D02398Zuclopenthixol--
BADD_D02407Upadacitinib--
BADD_D02412Octreotide0.001770%
BADD_D02428Loperamide0.001082%
BADD_D02432Glycopyrronium0.023074%
BADD_D02434Cinacalcet0.106249%
BADD_D02436Atorvastatin--
BADD_D02439Levodopa0.001101%
BADD_D02442Magnesium oxide0.000638%
BADD_D02443Tiotropium--
BADD_D02445Solifenacin0.008195%
BADD_D02451Pimavanserin0.020749%
BADD_D02453Midostaurin0.001007%
BADD_D02462Methylnaltrexone0.003644%
BADD_D02466Levomilnacipran0.000212%
BADD_D02467Naloxegol0.016026%
BADD_D02468Cannabidiol0.008966%
BADD_D02470Nintedanib0.007051%
BADD_D02480Alectinib0.003324%
BADD_D02483Ribociclib0.005227%
BADD_D02484Istradefylline0.041055%
BADD_D02489Neratinib0.018132%
BADD_D02490Apalutamide--
BADD_D02492Deflazacort0.001927%
BADD_D02493Selinexor0.000951%
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