Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Dental caries
ADR ID BADD_A01196
ADR Hierarchy
07      Gastrointestinal disorders
07.09      Dental and gingival conditions
07.09.01      Dental and periodontal infections and inflammations
07.09.01.001      Dental caries
Description A disorder characterized by the decay of a tooth, in which it becomes softened, discolored and/or porous. [CTCAE] Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp. [MeSH]
MedDRA Code 10012318
MeSH ID D003731
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Caries dental | Cavity | Cavity NOS | Decay dental | Dental caries | Dental caries aggravated | Tooth caries | Tooth caries aggravated | Tooth caries aggravated NOS | Tooth caries NOS | Tooth decay | Tooth cavity | Dental decay | Dental cavity | Carious lesion | Dental caries Black's class 1 | Dental Caries | Dental Decay | Caries, Dental | Decay, Dental | Carious Dentin | Carious Dentins | Dentin, Carious | Dentins, Carious | Dental White Spot | White Spots, Dental | White Spots | Spot, White | Spots, White | White Spot | Dental White Spots | White Spot, Dental
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01431Methylphenidate0.000160%
BADD_D01465Miglustat0.004312%
BADD_D01471Minocycline anion--
BADD_D01476Mirtazapine0.000080%
BADD_D01564Nicotine0.004137%
BADD_D01567Nilotinib0.000851%
BADD_D01599Olanzapine0.000210%
BADD_D01645Oxycodone0.000180%
BADD_D01646Oxycodone hydrochloride--
BADD_D01654Palbociclib0.000683%
BADD_D01679Paroxetine--
BADD_D01680Paroxetine hydrochloride--
BADD_D01681Paroxetine hydrochloride hemihydrate--
BADD_D01682Paroxetine impurity a--
BADD_D01683Paroxetine mesylate--
BADD_D01735Pergolide--
BADD_D01736Pergolide mesylate--
BADD_D01738Periciazine--
BADD_D01798Pomalidomide0.001881%
BADD_D01817Pramipexole--
BADD_D01818Pramipexole dihydrochloride--
BADD_D01831Prednisolone0.000035%
BADD_D01835Pregabalin0.000674%
BADD_D01888Quetiapine0.000278%
BADD_D01889Quetiapine fumarate--
BADD_D01898Rabeprazole--
BADD_D01922Regorafenib0.000112%
BADD_D01942Riluzole--
BADD_D01956Rivastigmine tartrate--
BADD_D01961Rofecoxib--
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