Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Fatigue
ADR ID BADD_A01626
ADR Hierarchy
08      General disorders and administration site conditions
08.01      General system disorders NEC
08.01.01      Asthenic conditions
08.01.01.002      Fatigue
Description A disorder characterized by a state of generalized weakness with a pronounced inability to summon sufficient energy to accomplish daily activities. [CTCAE] The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli. [MeSH]
MedDRA Code 10016256
MeSH ID D005221
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Enervation | Exhaustion | Exhaustion due to excessive exertion | Exhaustion due to exposure | Fatigability | Fatigability generalized | Fatigability lumbar | Fatigability of knees | Fatigue | Fatigue extreme | Fatiguability | Lassitude | Loss physical strength | Prostration | TATT | Tired all the time | Tired and heavy | Tired out | Tiredness | Washed-out | Weariness | Worn out | Fatigue aggravated | Depressive weariness | Fatigueability generalised | Chronic fatigue | Fatiguability generalised
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02397Zopiclone--
BADD_D02398Zuclopenthixol--
BADD_D02401Coenzyme M0.000184%
BADD_D02407Upadacitinib--
BADD_D02412Octreotide0.007861%
BADD_D02428Loperamide--
BADD_D02440Lisdexamfetamine0.007955%
BADD_D02445Solifenacin--
BADD_D02452Icatibant--
BADD_D02464Fingolimod0.368372%
BADD_D02468Cannabidiol0.022814%
BADD_D02470Nintedanib0.013185%
BADD_D02472Sonidegib0.001231%
BADD_D02473Sodium chloride--
BADD_D02480Alectinib0.004500%
BADD_D02482Acalabrutinib0.002630%
BADD_D02483Ribociclib0.019509%
BADD_D02484Istradefylline0.031479%
BADD_D02485Talazoparib0.001399%
BADD_D02487Baricitinib--
BADD_D02489Neratinib0.029739%
BADD_D02490Apalutamide0.061030%
BADD_D02491Valbenazine0.134479%
BADD_D02493Selinexor0.007141%
BADD_D02495Duvelisib0.001477%
BADD_D02496Elagolix--
BADD_D02497Avatrombopag0.007225%
BADD_D02498Abemaciclib0.022184%
BADD_D02500Alpelisib0.011853%
BADD_D02503Telotristat ethyl-
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ADReCS-Target
ADR Term Drug Name Target