Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Generalised tonic-clonic seizure
ADR ID BADD_A01810
ADR Hierarchy
17      Nervous system disorders
17.12      Seizures (incl subtypes)
17.12.01      Generalised tonic-clonic seizures
17.12.01.002      Generalised tonic-clonic seizure
Description Recurrent conditions characterized by epileptic seizures which arise diffusely and simultaneously from both hemispheres of the brain. Classification is generally based upon motor manifestations of the seizure (e.g., convulsive, nonconvulsive, akinetic, atonic, etc.) or etiology (e.g., idiopathic, cryptogenic, and symptomatic). (From Mayo Clin Proc, 1996 Apr;71(4):405-14) [MeSH]
MedDRA Code 10018100
MeSH ID D004829; D004830; D012640
ADR Severity Grade (FAERS) Not Available
ADR Severity Grade (CTCAE) Not Available
Synonym
Clonic-tonic convulsions | Convulsion grand mal | Convulsions grand mal | Epilepsy grand mal | Generalised tonic-clonic seizure | Generalized convulsive epilepsy | Generalized convulsive epilepsy, with intractable epilepsy | Generalized convulsive epilepsy, without mention of intractable epilepsy | Grand mal | Grand mal convulsion | Grand mal epilepsy | Grand mal epileptic fit | Grand mal fit | Grand mal seizure | Major convulsion | Seizure grand mal | Tonic-clonic convulsion | Tonic-clonic epilepsy | Tonic-clonic seizures | Tonic/ clonic convulsions | Generalized tonic-clonic seizure | Generalised convulsive epilepsy | Generalised onset motor seizure | Generalized onset motor seizure | Epilepsy, Generalized | Epilepsies, Generalized | Generalized Epilepsies | Generalized Epilepsy | Seizure Disorder, Generalized | Generalized Seizure Disorder | Generalized Seizure Disorders | Seizure Disorders, Generalized | Epilepsy, Akinetic | Akinetic Epilepsies | Akinetic Epilepsy | Epilepsies, Akinetic | Symptomatic Generalized Epilepsy | Epilepsy, Symptomatic Generalized | Generalized Epilepsy, Symptomatic | Epilepsy, Tonic | Epilepsies, Tonic | Tonic Epilepsies | Tonic Epilepsy | Generalized Nonconvulsive Seizure Disorder | Generalized Seizure Disorder, Nonconvulsive | Seizure Disorder, Nonconvulsive Generalized | Nonconvulsive Seizure Disorder, Generalized | Seizure Disorder, Generalized Nonconvulsive | Generalized Nonconvulsive Epilepsy | Epilepsy, Generalized Nonconvulsive | Nonconvulsive Epilepsy, Generalized | Nonconvulsive Generalized Seizure Disorder | Convulsive Generalized Seizure Disorder | Generalized Convulsive Epilepsy | Convulsive Epilepsies, Generalized | Convulsive Epilepsy, Generalized | Epilepsies, Generalized Convulsive | Epilepsy, Generalized Convulsive | Generalized Convulsive Epilepsies | Generalized Onset Seizure Disorder | Seizure Disorder, Convulsive, Generalized | Seizure Disorder, Generalized Onset | Seizure Disorder, Generalized, Convulsive | Convulsive Seizure Disorder, Generalized | Generalized Seizure Disorder, Convulsive | Epilepsy, Atonic | Atonic Epilepsies | Atonic Epilepsy | Epilepsies, Atonic
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01433Methylprednisolone0.000096%
BADD_D01442Metoclopramide0.000686%
BADD_D01449Metronidazole0.000184%
BADD_D01461Midodrine0.002268%
BADD_D01465Miglustat0.008625%
BADD_D01466Milnacipran hydrochloride--
BADD_D01476Mirtazapine0.000240%
BADD_D01502Moxifloxacin hydrochloride--
BADD_D01525Naloxone0.000648%
BADD_D01526Naloxone hydrochloride--
BADD_D01546Nefazodone--
BADD_D01547Nefazodone hydrochloride--
BADD_D01549Nelarabine--
BADD_D01572Nitisinone0.006469%
BADD_D01599Olanzapine0.001789%
BADD_D01617Ondansetron--
BADD_D01618Ondansetron hydrochloride--
BADD_D01633Oxaliplatin0.000616%
BADD_D01637Oxcarbazepine0.001363%
BADD_D01643Oxybutynin0.000056%
BADD_D01653Paclitaxel--
BADD_D01656Paliperidone--
BADD_D01657Paliperidone palmitate--
BADD_D01679Paroxetine0.000043%
BADD_D01680Paroxetine hydrochloride--
BADD_D01681Paroxetine hydrochloride hemihydrate--
BADD_D01682Paroxetine impurity a--
BADD_D01683Paroxetine mesylate--
BADD_D01710Penicillin g0.003992%
BADD_D01719Pentazocine hydrochloride--
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