Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Hepatic necrosis
ADR ID BADD_A02009
ADR Hierarchy
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.07      Hepatocellular damage and hepatitis NEC
09.01.07.002      Hepatic necrosis
Description A disorder characterized by a necrotic process occurring in the hepatic parenchyma. [CTCAE]
MedDRA Code 10019692
MeSH ID Not Available
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Acute and subacute necrosis of liver | Hepatic lobule necrosis | Hepatic necrosis | Hepatic necrosis extensive | Hepatitis necrotizing | Liver necrosis | Necrosis hepatocellular | Necrosis liver | Necrosis liver focal | Subacute hepatic necrosis | Hepatitis necrotising
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00981Gabapentin0.000010%
BADD_D01009Gemcitabine0.000112%
BADD_D01057Halothane--
BADD_D01081Hydralazine0.000102%
BADD_D01120Ibuprofen--
BADD_D01130Idelalisib0.000392%
BADD_D01136Imatinib0.000448%
BADD_D01137Imatinib mesylate--
BADD_D01203Isoflurane--
BADD_D01204Isoniazid0.013065%
BADD_D01230Ketoconazole--
BADD_D01236Labetalol--
BADD_D01237Labetalol hydrochloride--
BADD_D01243Lamotrigine0.000138%
BADD_D01252Leflunomide--
BADD_D01265Levetiracetam0.000079%
BADD_D01275Levofloxacin0.000105%
BADD_D01285Levothyroxine0.000005%
BADD_D01309Lomefloxacin--
BADD_D01325Lovastatin--
BADD_D01392Mercaptopurine0.001041%
BADD_D01397Mesalamine--
BADD_D01410Methazolamide--
BADD_D01445Metoprolol0.000010%
BADD_D01449Metronidazole0.000079%
BADD_D01453Mexiletine hydrochloride--
BADD_D01470Minocycline0.000295%
BADD_D01498Morphine0.000167%
BADD_D01501Moxifloxacin--
BADD_D01502Moxifloxacin hydrochloride--
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ADReCS-Target
ADR Term Drug Name Target