Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Hepatorenal syndrome
ADR ID BADD_A02051
ADR Hierarchy
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.03      Hepatic failure and associated disorders
09.01.03.007      Hepatorenal syndrome
20      Renal and urinary disorders
20.01      Renal disorders (excl nephropathies)
20.01.03      Renal failure and impairment
20.01.03.012      Hepatorenal syndrome
Description Functional KIDNEY FAILURE in patients with liver disease, usually LIVER CIRRHOSIS or portal hypertension (HYPERTENSION, PORTAL), and in the absence of intrinsic renal disease or kidney abnormality. It is characterized by intense renal vasculature constriction, reduced renal blood flow, OLIGURIA, and sodium retention. [MeSH]
MedDRA Code 10019846
MeSH ID D006530
ADR Severity Grade (FAERS) Not Available
ADR Severity Grade (CTCAE) Not Available
Synonym
Hepatorenal syndrome | Syndrome hepatorenal | Hepatorenal syndrome type 1 | Hepatorenal syndrome type 2 | Hepatorenal Syndrome | Syndrome, Hepatorenal
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02053Sofosbuvir0.001835%
BADD_D02058Sorafenib0.000336%
BADD_D02066Spironolactone0.000037%
BADD_D02100Sunitinib0.000112%
BADD_D02105Tacrolimus0.000594%
BADD_D02150Temozolomide0.000112%
BADD_D02154Tenofovir0.005816%
BADD_D02215Ticlopidine--
BADD_D02246Tolvaptan0.000145%
BADD_D02367Voltaren--
BADD_D02373Warfarin0.000042%
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