Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Hyperbilirubinaemia
ADR ID BADD_A02109
ADR Hierarchy
01      Blood and lymphatic system disorders
01.06      Haemolyses and related conditions
01.06.04      Haemolyses NEC
01.06.04.003      Hyperbilirubinaemia
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.01      Cholestasis and jaundice
09.01.01.003      Hyperbilirubinaemia
14      Metabolism and nutrition disorders
14.11      Metabolism disorders NEC
14.11.01      Metabolic disorders NEC
14.11.01.010      Hyperbilirubinaemia
Description A condition characterized by an abnormal increase of BILIRUBIN in the blood, which may result in JAUNDICE. Bilirubin, a breakdown product of HEME, is normally excreted in the BILE or further catabolized before excretion in the urine. [MeSH]
MedDRA Code 10020578
MeSH ID D006932
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Aggravated bilirubinemia | Bilirubinaemia | Bilirubinaemia aggravated | Bilirubinemia | Bilirubinemia aggravated | Conjugated bilirubinaemia | Hyper bilirubinaemia | Hyperbilirubinaemia | Hyperbilirubinaemia aggravated | Hyperbilirubinemia | Unconjugated bilirubinaemia | Unconjugated bilirubinemia | Hyperbilirubinemia aggravated | Conjugated bilirubinemia | Direct hyperbilirubinemia | Indirect hyperbilirubinemia | Direct hyperbilirubinaemia | Indirect hyperbilirubinaemia | Hyperbilirubinemias | Bilirubinemias
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02226Tipranavir--
BADD_D02227Tipranavir disodium--
BADD_D02249Topotecan hydrochloride--
BADD_D02253Trabectedin0.000112%
BADD_D02257Trametinib--
BADD_D02258Trametinib dimethyl sulfoxide--
BADD_D02266Trazodone--
BADD_D02267Trazodone hydrochloride--
BADD_D02307Trovafloxacin--
BADD_D02308Trovafloxacin mesylate--
BADD_D02329Valproic acid0.000300%
BADD_D02344Vemurafenib0.000224%
BADD_D02345Venetoclax0.000604%
BADD_D02346Venlafaxine--
BADD_D02360Vincristine0.000224%
BADD_D02365Vismodegib0.000224%
BADD_D02369Voriconazole0.055181%
BADD_D02377Zafirlukast--
BADD_D02378Zalcitabine--
BADD_D02379Zaleplon--
BADD_D02383Zidovudine--
BADD_D02384Zileuton--
BADD_D02394Zolpidem--
BADD_D02395Zolpidem tartrate--
BADD_D02412Octreotide0.000186%
BADD_D02428Loperamide--
BADD_D02453Midostaurin0.000168%
BADD_D02464Fingolimod0.001326%
BADD_D02470Nintedanib0.000302%
BADD_D02480Alectinib0.000951%
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