Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Hyperkeratosis
ADR ID BADD_A02126
ADR Hierarchy
23      Skin and subcutaneous tissue disorders
23.01      Cornification and dystrophic skin disorders
23.01.01      Hyperkeratoses
23.01.01.001      Hyperkeratosis
Description A disorder characterized by a thickening of the outer layer of the skin. [CTCAE] Localized hyperplasia of the horny layer of the epidermis due to pressure or friction. (Dorland, 27th ed) [MeSH]
MedDRA Code 10020649
MeSH ID D002145; D002146; D007642; D015776
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Acquired keratoderma | Callosities | Callosity | Callus | Corns | Corns and callosities | Cutaneous horn | Erythrokeratoderma | Foot callus | Hard corn | Hyperkeratosis | Keratoderma | Keratoderma, acquired | Keratosis | Skin keratosis | Soft corn | Tyloma | Tylosis | Skin callus | Clavus | Heloma molle
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02254Tramadol--
BADD_D02257Trametinib--
BADD_D02258Trametinib dimethyl sulfoxide--
BADD_D02329Valproic acid0.000100%
BADD_D02344Vemurafenib0.005988%
BADD_D02348Verapamil--
BADD_D02349Verapamil hydrochloride--
BADD_D02369Voriconazole0.008713%
BADD_D02392Zoledronic acid0.008589%
BADD_D02464Fingolimod0.002435%
BADD_D02591Ripretinib0.002205%
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