Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Hypoaldosteronism
ADR ID BADD_A02179
ADR Hierarchy
05      Endocrine disorders
05.01      Adrenal gland disorders
05.01.02      Adrenal cortical hypofunctions
05.01.02.009      Hypoaldosteronism
14      Metabolism and nutrition disorders
14.11      Metabolism disorders NEC
14.11.01      Metabolic disorders NEC
14.11.01.031      Hypoaldosteronism
Description A congenital or acquired condition of insufficient production of ALDOSTERONE by the ADRENAL CORTEX leading to diminished aldosterone-mediated synthesis of Na(+)-K(+)-EXCHANGING ATPASE in renal tubular cells. Clinical symptoms include HYPERKALEMIA, sodium-wasting, HYPOTENSION, and sometimes metabolic ACIDOSIS. | A selective aldosterone deficiency resulting from diminished RENIN-generated ANGIOTENSIN II, a key stimulus to aldosterone secretion. Previously, it was called type IV renal tubular acidosis. [MeSH]
MedDRA Code 10020944
MeSH ID D006994
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Hypoaldosteronism | Hyporeninemic hypoaldosteronism | Hyperreninemic hypoaldosteronism | Hyperreninaemic hypoaldosteronism | Hyporeninaemic hypoaldosteronism | Hypoaldosteronemia | Hypoaldosteronaemia | Hypoaldosteronism, Hyporeninemic | Type IV Renal Tubular Acidosis | Renal Tubular Acidosis, Type IV | Acidosis, Renal Tubular Type IV | Hyporeninemic Hypoaldosteronism
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00623Dexamethasone0.000145%
BADD_D00974Fragmin--
BADD_D01217Itraconazole0.005879%
BADD_D01300Lisinopril0.000005%
BADD_D01684Pasireotide0.000186%
BADD_D02105Tacrolimus0.000446%
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