Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Lichen planus
ADR ID BADD_A02526
ADR Hierarchy
23      Skin and subcutaneous tissue disorders
23.03      Epidermal and dermal conditions
23.03.08      Papulosquamous conditions
23.03.08.001      Lichen planus
Description An inflammatory, pruritic disease of the skin and mucous membranes, which can be either generalized or localized. It is characterized by distinctive purplish, flat-topped papules having a predilection for the trunk and flexor surfaces. The lesions may be discrete or coalesce to form plaques. Histologically, there is a "saw-tooth" pattern of epidermal hyperplasia and vacuolar alteration of the basal layer of the epidermis along with an intense upper dermal inflammatory infiltrate composed predominantly of T-cells. Etiology is unknown. [MeSH]
MedDRA Code 10024429
MeSH ID D008010
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Hypertrophic lichen planus | Lichen planus | Lichen planus aggravated | Papule red lichenoid | Wickham's striae | Erythematous lichen planus | Atrophic lichen planus | Bullous lichen planus | Lichen ruber verrucosus | Erosive lichen planus | Lichen ruber moniliformis | Lichen Planus | Lichen Ruber Planus | Lichen Rubra Planus
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01401Metformin0.000039%
BADD_D01418Methotrexate--
BADD_D01533Naproxen--
BADD_D01534Naproxen sodium--
BADD_D01567Nilotinib0.000246%
BADD_D01709Penicillamine--
BADD_D01827Prazosin--
BADD_D01828Prazosin hydrochloride--
BADD_D01834Prednisone0.000020%
BADD_D01895Quinine--
BADD_D01909Ramipril--
BADD_D01933Ribavirin0.011868%
BADD_D02010Sertraline0.000043%
BADD_D02026Simvastatin0.000015%
BADD_D02029Sitagliptin0.000053%
BADD_D02093Sulfasalazine--
BADD_D02160Terbinafine0.000521%
BADD_D02331Valsartan0.000079%
BADD_D02346Venlafaxine0.000032%
BADD_D02464Fingolimod0.000241%
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