Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Linear IgA disease
ADR ID BADD_A02537
ADR Hierarchy
10      Immune system disorders
10.04      Autoimmune disorders
10.04.02      Skin autoimmune disorders NEC
10.04.02.006      Linear IgA disease
23      Skin and subcutaneous tissue disorders
23.03      Epidermal and dermal conditions
23.03.01      Bullous conditions
23.03.01.015      Linear IgA disease
Description Autoimmune disease characterized by subepidermal blisters and linear deposition of autoantibodies at the dermoepidermal junction. The accumulated autoantibodies are of IMMUNOGLOBULIN A and occasionally IMMUNOGLOBULIN G classes against epidermal BASEMENT MEMBRANE proteins. The dermatosis is sometimes associated with malignancies and use of certain drugs (e.g., VANCOMYCIN). [MeSH]
MedDRA Code 10024515
MeSH ID D062027
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Linear Ig A disease | Linear IgA | Linear IgA bullous disease of childhood | Linear IgA disease | Linear IgA bullous dermatosis | Chronic bullous disease of childhood | Linear IgA/IgG bullous dermatosis | Linear IgA Bullous Dermatosis | Linear IgA Dermatosis | Dermatoses, Linear IgA | Dermatosis, Linear IgA | IgA Dermatoses, Linear | IgA Dermatosis, Linear | Linear IgA Dermatoses | Drug-induced Linear IgA Bullous Dermatosis | Drug induced Linear IgA Bullous Dermatosis | Drug-induced Linear IgA Dermatosis | Drug induced Linear IgA Dermatosis | Linear IgA IgG Bullous Dermatosis | Linear IgA IgG Dermatosis | Chronic Bullous Disease of Childhood
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00033Acetylsalicylic acid0.000022%
BADD_D00103Amikacin0.000253%
BADD_D00121Amlodipine0.000010%
BADD_D00129Amoxicillin0.000038%
BADD_D00379Cefadroxil0.000558%
BADD_D00386Cefepime0.000073%
BADD_D00407Cefuroxime0.000816%
BADD_D00653Diclofenac0.000102%
BADD_D00668Digoxin0.000105%
BADD_D00802Ertapenem0.000049%
BADD_D01012Gemfibrozil0.000161%
BADD_D01142Imiquimod0.000658%
BADD_D01194Irbesartan0.000189%
BADD_D01231Ketoprofen0.006721%
BADD_D01275Levofloxacin0.000169%
BADD_D01374Meloxicam0.000016%
BADD_D01393Meropenem0.000146%
BADD_D01449Metronidazole0.000184%
BADD_D01470Minocycline0.000177%
BADD_D01598Ofloxacin0.000125%
BADD_D01765Phenytoin0.000191%
BADD_D02020Silodosin0.000848%
BADD_D02029Sitagliptin0.000053%
BADD_D02160Terbinafine0.000596%
BADD_D02332Vancomycin--
BADD_D02333Vancomycin hydrochloride--
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