Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Muscle rigidity
ADR ID BADD_A02887
ADR Hierarchy
15      Musculoskeletal and connective tissue disorders
15.05      Muscle disorders
15.05.04      Muscle tone abnormalities
15.05.04.001      Muscle rigidity
17      Nervous system disorders
17.05      Neuromuscular disorders
17.05.02      Muscle tone abnormal
17.05.02.005      Muscle rigidity
Description Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73) [MeSH]
MedDRA Code 10028330
MeSH ID D009127
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Lead pipe rigidity | Marked rigidity | Muscle rigidity | Muscular rigidity spastic | Plastic rigidity | Rigidity | Rigidity bodily | Rigidity muscle | Rigidity of limbs | Muscular rigor | Muscular rigour | Muscle Rigidity | Rigidity, Muscle | Rigidity, Muscular | Muscular Rigidity | Cogwheel Rigidity | Cogwheel Rigidities | Rigidities, Cogwheel | Rigidity, Cogwheel | Nuchal Rigidity | Rigidity, Nuchal | Extrapyramidal Rigidity | Rigidity, Extrapyramidal | Gegenhalten | Gegenhaltens | Catatonic Rigidity | Rigidity, Catatonic | Extensor Rigidity | Rigidity, Extensor
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01536Naratriptan hydrochloride--
BADD_D01585Norethindrone--
BADD_D01599Olanzapine0.004841%
BADD_D01633Oxaliplatin0.001399%
BADD_D01636Oxazepam0.003800%
BADD_D01637Oxcarbazepine0.000170%
BADD_D01645Oxycodone--
BADD_D01656Paliperidone0.046168%
BADD_D01657Paliperidone palmitate--
BADD_D01679Paroxetine--
BADD_D01738Periciazine--
BADD_D01743Perphenazine--
BADD_D01750Phenelzine--
BADD_D01751Phenelzine sulfate--
BADD_D01774Pimozide--
BADD_D01817Pramipexole0.001659%
BADD_D01818Pramipexole dihydrochloride--
BADD_D01835Pregabalin0.000337%
BADD_D01848Prochlorperazine--
BADD_D01854Promethazine0.000058%
BADD_D01864Propofol0.001322%
BADD_D01867Propranolol0.000118%
BADD_D01888Quetiapine0.000327%
BADD_D01909Ramipril0.000093%
BADD_D01916Rasagiline mesylate--
BADD_D01923Remifentanil hydrochloride--
BADD_D01951Risperidone0.004595%
BADD_D01955Rivastigmine0.002981%
BADD_D01956Rivastigmine tartrate--
BADD_D01959Rocuronium0.000125%
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