Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Muscle spasticity
ADR ID BADD_A02890
ADR Hierarchy
15      Musculoskeletal and connective tissue disorders
15.05      Muscle disorders
15.05.04      Muscle tone abnormalities
15.05.04.011      Muscle spasticity
17      Nervous system disorders
17.05      Neuromuscular disorders
17.05.03      Neuromuscular disorders NEC
17.05.03.007      Muscle spasticity
Description A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a "free interval") followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54) [MeSH]
MedDRA Code 10028335
MeSH ID D009128
ADR Severity Grade (FAERS) Not Available
ADR Severity Grade (CTCAE)
Synonym
Finger spasticity | Leg spasticity | Muscle spasticity | Muscle spasticity aggravated | Spasticity | Spasticity muscle | Arm spasticity | Cortical thumbing | Leg scissoring | Muscle Spasticity | Spasticity, Muscle | Spastic | Clasp-Knife Spasticity | Clasp Knife Spasticity | Spasticity, Clasp-Knife
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00023Acetaminophen--
BADD_D00085Alprazolam--
BADD_D00209Baclofen0.043658%
BADD_D00356Carbamazepine--
BADD_D00364Carboplatin0.000168%
BADD_D00445Chlorpromazine--
BADD_D00471Ciprofloxacin--
BADD_D00479Cladribine0.000336%
BADD_D00501Clonazepam0.000131%
BADD_D00574Dalfampridine0.010875%
BADD_D00647Diatrizoic acid--
BADD_D00648Diazepam0.000126%
BADD_D00653Diclofenac--
BADD_D00676Dimenhydrinate--
BADD_D00680Dimethyl fumarate0.011242%
BADD_D00716Doxapram--
BADD_D00717Doxapram hydrochloride--
BADD_D00809Escitalopram0.000061%
BADD_D00864Ezetimibe0.000094%
BADD_D00981Gabapentin--
BADD_D00984Gadobutrol0.007113%
BADD_D01054Haloperidol--
BADD_D01096Hydromorphone0.000962%
BADD_D01180Iohexol--
BADD_D01181Iopamidol--
BADD_D01238Lacosamide0.001463%
BADD_D01318Lorazepam0.000031%
BADD_D01405Methadone0.000663%
BADD_D01431Methylphenidate--
BADD_D01465Miglustat0.006469%
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