Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Myelofibrosis
ADR ID BADD_A02928
ADR Hierarchy
01      Blood and lymphatic system disorders
01.13      Haematopoietic neoplasms (excl leukaemias and lymphomas)
01.13.03      Myeloproliferative disorders (excl leukaemias)
01.13.03.005      Myelofibrosis
16      Neoplasms benign, malignant and unspecified (incl cysts and polyps)
16.21      Haematopoietic neoplasms (excl leukaemias and lymphomas)
16.21.03      Myeloproliferative disorders (excl leukaemias)
16.21.03.001      Myelofibrosis
Description A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone. [MeSH]
MedDRA Code 10028537
MeSH ID D055728
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Acute myelofibrosis | Myelofibrosis | Myelofibrosis with myelometaplasia | Osteomyelofibrosis | Osteomyelosclerosis | Post polycythemia vera myelofibrosis | Post essential thrombocythemia myelofibrosis | Post polycythaemia vera myelofibrosis | Post essential thrombocythaemia myelofibrosis | Primary Myelofibrosis | Myelofibroses, Primary | Myelofibrosis, Primary | Primary Myelofibroses | Bone Marrow Fibrosis | Bone Marrow Fibroses | Fibroses, Bone Marrow | Fibrosis, Bone Marrow | Myelofibroses | Idiopathic Myelofibrosis | Myeloid Metaplasia | Metaplasia, Myeloid | Metaplasias, Myeloid | Myeloid Metaplasias | Myelosclerosis | Myeloscleroses | Myelosis, Nonleukemic | Myeloses, Nonleukemic | Nonleukemic Myeloses | Nonleukemic Myelosis | Chronic Idiopathic Myelofibrosis | Agnogenic Myeloid Metaplasia | Agnogenic Myeloid Metaplasias | Metaplasia, Agnogenic Myeloid | Metaplasias, Agnogenic Myeloid | Myeloid Metaplasia, Agnogenic | Myeloid Metaplasias, Agnogenic | Myelofibrosis With Myeloid Metaplasia
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00139Anagrelide0.000672%
BADD_D00142Anastrozole0.000159%
BADD_D00194Azacitidine0.001007%
BADD_D00364Carboplatin0.000224%
BADD_D00560Cytarabine0.000112%
BADD_D00594Deferasirox0.013011%
BADD_D00759Eltrombopag0.000800%
BADD_D00979Furosemide0.000014%
BADD_D01110Hydroxyurea0.002295%
BADD_D01119Ibrutinib0.000112%
BADD_D01136Imatinib0.001063%
BADD_D01253Lenalidomide--
BADD_D01257Letrozole0.000263%
BADD_D01322Losartan0.000010%
BADD_D01452Mexiletine--
BADD_D01453Mexiletine hydrochloride--
BADD_D01567Nilotinib0.000392%
BADD_D01834Prednisone0.000018%
BADD_D01835Pregabalin--
BADD_D01847Procarbazine hydrochloride--
BADD_D01978Ruxolitinib0.007095%
BADD_D02007Semaxanib--
BADD_D02105Tacrolimus0.000743%
BADD_D02192Thalidomide0.001784%
BADD_D02554Fedratinib0.000492%
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