Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Osteonecrosis
ADR ID BADD_A03221
ADR Hierarchy
15      Musculoskeletal and connective tissue disorders
15.02      Bone disorders (excl congenital and fractures)
15.02.04      Bone disorders NEC
15.02.04.007      Osteonecrosis
24      Vascular disorders
24.04      Arteriosclerosis, stenosis, vascular insufficiency and necrosis
24.04.05      Musculoskeletal necrosis and vascular insufficiency
24.04.05.004      Osteonecrosis
Description A disorder characterized by necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure. [CTCAE] Death of a bone or part of a bone, either atraumatic or posttraumatic. | Osteonecrosis of the lunate. [MeSH]
MedDRA Code 10031264
MeSH ID D010020
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Aseptic necrosis | Aseptic necrosis bone | Aseptic necrosis of bone | Aseptic necrosis of bone, site unspecified | Aseptic necrosis of head and neck of femur | Aseptic necrosis of head of humerus | Aseptic necrosis of medial femoral condyle | Aseptic necrosis of other bone sites | Aseptic necrosis of talus | Avascular necrosis femoral head | Avascular necrosis of bone | Bone necrosis | Necrosis bone | Osteonecrosis | Avascular necrosis | Metacarpal collapse | Spontaneous osteonecrosis of knee | Morbus Ahlbaeck | Femoral head necrosis | Osteonecroses | Bone Necrosis | Bone Necroses | Necroses, Bone | Necrosis, Bone | Necrosis, Avascular, of Bone | Avascular Necrosis of Bone | Bone Avascular Necrosis | Kienbock Disease | Kienbock's Disease | Kienboeck Disease | Kienboeck's Disease | Kienboecks Disease | Necrosis, Aseptic, of Bone | Aseptic Necrosis of Bone | Bone Aseptic Necrosis
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02373Warfarin0.000084%
BADD_D02383Zidovudine0.004421%
BADD_D02392Zoledronic acid0.090754%
BADD_D02407Upadacitinib0.000241%
BADD_D02411Voxelotor-
BADD_D02480Alectinib0.000112%
BADD_D02482Acalabrutinib0.000112%
BADD_D02487Baricitinib0.000241%
BADD_D02539Calcium0.000391%
BADD_D02586Radium ra-223 dichloride-
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