Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Paroxysmal nocturnal haemoglobinuria
ADR ID BADD_A03317
ADR Hierarchy
01      Blood and lymphatic system disorders
01.06      Haemolyses and related conditions
01.06.03      Anaemias haemolytic NEC
01.06.03.003      Paroxysmal nocturnal haemoglobinuria
20      Renal and urinary disorders
20.02      Urinary tract signs and symptoms
20.02.01      Urinary abnormalities
20.02.01.022      Paroxysmal nocturnal haemoglobinuria
24      Vascular disorders
24.01      Embolism and thrombosis
24.01.01      Non-site specific embolism and thrombosis
24.01.01.015      Paroxysmal nocturnal haemoglobinuria
Description A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins. [MeSH]
MedDRA Code 10034042
MeSH ID D006457
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Paroxysmal nocturnal haemoglobinuria | Paroxysmal nocturnal hemoglobinuria | Hemoglobinuria, Paroxysmal | Paroxysmal Hemoglobinuria | Paroxysmal Cold Hemoglobinuria | Hemoglobinuria, Paroxysmal Cold | Paroxysmal Hemoglobinuria, Cold | Cold Paroxysmal Hemoglobinuria | Hemoglobinuria, Cold Paroxysmal | Paroxysmal Nocturnal Hemoglobinuria | Hemoglobinuria, Paroxysmal Nocturnal | Marchiafava-Micheli Syndrome | Marchiafava Micheli Syndrome | Syndrome, Marchiafava-Micheli | Paroxysmal Hemoglobinuria, Nocturnal | Hemoglobinuria, Nocturnal Paroxysmal | Nocturnal Paroxysmal Hemoglobinuria
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00430Chloramphenicol--
BADD_D00504Clopidogrel0.000021%
BADD_D00551Cyclosporine0.000718%
BADD_D00594Deferasirox0.001239%
BADD_D00759Eltrombopag0.000343%
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