Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Phaeochromocytoma
ADR ID BADD_A03403
ADR Hierarchy
05      Endocrine disorders
05.01      Adrenal gland disorders
05.01.04      Adrenal neoplasms
05.01.04.004      Phaeochromocytoma
16      Neoplasms benign, malignant and unspecified (incl cysts and polyps)
16.24      Endocrine neoplasms malignant and unspecified
16.24.02      Islet cell neoplasms and APUDoma NEC
16.24.02.004      Phaeochromocytoma
Description A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298) [MeSH]
MedDRA Code 10034800
MeSH ID D010673
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Phaeochromocytoma | Phaeochromocytoma aggravated | Pheochromocytoma | Pheochromocytomas | Pheochromocytoma, Extra-Adrenal | Extra-Adrenal Pheochromocytoma | Extra-Adrenal Pheochromocytomas | Pheochromocytoma, Extra Adrenal | Pheochromocytomas, Extra-Adrenal
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00056Albuterol0.000006%
BADD_D00165Aripiprazole0.000119%
BADD_D00356Carbamazepine0.000186%
BADD_D00374Carvedilol0.000031%
BADD_D00511Clozapine--
BADD_D00947Fluticasone propionate0.000184%
BADD_D01136Imatinib0.000168%
BADD_D01401Metformin0.000016%
BADD_D01433Methylprednisolone0.000032%
BADD_D01442Metoclopramide0.001274%
BADD_D01445Metoprolol0.000023%
BADD_D01834Prednisone0.000013%
BADD_D01867Propranolol0.000053%
BADD_D01954Rivaroxaban0.000095%
BADD_D02100Sunitinib0.000112%
BADD_D02192Thalidomide0.000241%
The 1th Page    1    Total 1 Pages