Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Porphyria non-acute
ADR ID BADD_A03512
ADR Hierarchy
03      Congenital, familial and genetic disorders
03.08      Metabolic and nutritional disorders congenital
03.08.01      Inborn errors of porphyrin metabolism
03.08.01.004      Porphyria non-acute
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.10      Hepatic metabolic disorders
09.01.10.003      Porphyria non-acute
14      Metabolism and nutrition disorders
14.14      Inborn errors of metabolism
14.14.01      Inborn errors of porphyrin metabolism
14.14.01.004      Porphyria non-acute
23      Skin and subcutaneous tissue disorders
23.03      Epidermal and dermal conditions
23.03.01      Bullous conditions
23.03.01.012      Porphyria non-acute
Description An autosomal dominant porphyria that is due to a deficiency of FERROCHELATASE (heme synthetase) in both the LIVER and the BONE MARROW, the last enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include mainly neurological symptoms, rarely cutaneous lesions, and elevated levels of protoporphyrin and COPROPORPHYRINS in the feces. [MeSH]
MedDRA Code 10036186
MeSH ID D046351; D017119
ADR Severity Grade (FAERS) Not Available
ADR Severity Grade (CTCAE) Not Available
Synonym
Cutaneous hepatic porphyria | Erythropoietic protoporphyria | Hematoporphyrinemia | Porphyria cutanea tarda | Porphyria hepatic | Porphyria hepatic aggravated | Porphyria non-acute | Porphyria non-acute aggravated | Haematoporphyrinaemia | Uroporphyrinogen decarboxylase deficiency | Protoporphyria, Erythropoietic | Erythropoietic Protoporphyrias | Protoporphyrias, Erythropoietic | Erythrohepatic Protoporphyria | Erythropoietic Protoporphyria | Ferrochelatase Deficiency | Deficiencies, Ferrochelatase | Deficiency, Ferrochelatase | Ferrochelatase Deficiencies | Heme Synthetase Deficiency | Deficiencies, Heme Synthetase | Deficiency, Heme Synthetase | Heme Synthetase Deficiencies | Synthetase Deficiencies, Heme | Synthetase Deficiency, Heme
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00283Boceprevir--
BADD_D00318Busulfan--
BADD_D00356Carbamazepine--
BADD_D00447Chlorpropamide--
BADD_D00821Estradiol--
BADD_D01022Gliclazide--
BADD_D01023Glimepiride--
BADD_D01024Glipizide--
BADD_D01030Glyburide--
BADD_D01533Naproxen--
BADD_D01534Naproxen sodium--
BADD_D01596Ofatumumab--
BADD_D02111Tamoxifen--
BADD_D02112Tamoxifen citrate--
BADD_D02238Tolazamide--
BADD_D02240Tolbutamide--
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