Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Progressive multifocal leukoencephalopathy
ADR ID BADD_A03557
ADR Hierarchy
11      Infections and infestations
11.05      Viral infectious disorders
11.05.05      Polyomavirus infections
11.05.05.001      Progressive multifocal leukoencephalopathy
17      Nervous system disorders
17.16      Demyelinating disorders
17.16.02      Demyelinating disorders NEC
17.16.02.002      Progressive multifocal leukoencephalopathy
Description An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7) [MeSH]
MedDRA Code 10036807
MeSH ID D007968
ADR Severity Grade (FAERS) Not Available
ADR Severity Grade (CTCAE) Not Available
Synonym
Progressive multifocal leucoencephalopathy | Progressive multifocal leukoencephalopathy | Leukoencephalopathy, Progressive Multifocal | Leukoencephalopathies, Progressive Multifocal | Multifocal Leukoencephalopathies, Progressive | Multifocal Leukoencephalopathy, Progressive | Progressive Multifocal Leukoencephalopathies | Progressive Multifocal Leukoencephalopathy | JC Polyomavirus Encephalopathy | Encephalopathies, JC Polyomavirus | Encephalopathy, JC Polyomavirus | Encephalitis, JC Polyomavirus | JC Polyomavirus Encephalitis
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00064Alemtuzumab--
BADD_D00223Belatacept--
BADD_D00284Bortezomib--
BADD_D00291Brentuximab vedotin--
BADD_D00551Cyclosporine--
BADD_D00586Darunavir--
BADD_D00680Dimethyl fumarate--
BADD_D00914Fludarabine--
BADD_D00915Fludarabine phosphate--
BADD_D01133Ifosfamide--
BADD_D01507Mycophenolate mofetil--
BADD_D01508Mycophenolic acid--
BADD_D01549Nelarabine--
BADD_D01596Ofatumumab--
BADD_D01953Rituximab--
BADD_D01989Saquinavir mesylate--
BADD_D02028Sirolimus--
BADD_D02105Tacrolimus--
BADD_D02227Tipranavir disodium--
BADD_D02342Vedolizumab--
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