Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Pulmonary hypertension
ADR ID BADD_A03637
ADR Hierarchy
22      Respiratory, thoracic and mediastinal disorders
22.06      Pulmonary vascular disorders
22.06.01      Pulmonary hypertensions
22.06.01.001      Pulmonary hypertension
24      Vascular disorders
24.08      Vascular hypertensive disorders
24.08.03      Pulmonary hypertensions
24.08.03.002      Pulmonary hypertension
Description A disorder characterized by an increase in pressure within the pulmonary circulation due to lung or heart disorder. [CTCAE] Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES. [MeSH]
MedDRA Code 10037400
MeSH ID D006976
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Hypertension pulmonary | Pulmonary hypertension | Pulmonary hypertension aggravated | Pulmonary hypertension NOS | Pulmonary hypertension NOS aggravated | Pulmonary hypertension secondary | Hypertension pulmonary aggravated | Chronic thromboembolic pulmonary hypertension | CTEPH | Pulmonary hypertension WHO functional class I | Pulmonary hypertension WHO functional class II | Pulmonary hypertension WHO functional class III | Pulmonary hypertension WHO functional class IV | Hypertension, Pulmonary | Pulmonary Hypertension
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00663Diethylpropion hydrochloride--
BADD_D00668Digoxin0.000158%
BADD_D00701Dofetilide0.000254%
BADD_D00730Dronedarone0.000490%
BADD_D00782Epinephrine0.000081%
BADD_D00788Epoprostenol0.001826%
BADD_D00809Escitalopram0.000057%
BADD_D00932Fluoxetine0.000118%
BADD_D00933Fluoxetine hydrochloride--
BADD_D00947Fluticasone propionate--
BADD_D01009Gemcitabine0.000168%
BADD_D01110Hydroxyurea0.000336%
BADD_D01120Ibuprofen0.000060%
BADD_D01133Ifosfamide--
BADD_D01135Iloprost0.003495%
BADD_D01136Imatinib0.000672%
BADD_D01137Imatinib mesylate--
BADD_D01156Indomethacin--
BADD_D01167Interferon alfa-2b--
BADD_D01182Iopromide--
BADD_D01217Itraconazole0.004008%
BADD_D01231Ketoprofen0.002240%
BADD_D01236Labetalol0.000163%
BADD_D01243Lamotrigine0.000304%
BADD_D01248Lapatinib0.000224%
BADD_D01252Leflunomide0.001071%
BADD_D01253Lenalidomide--
BADD_D01260Leuprolide acetate--
BADD_D01318Lorazepam--
BADD_D01336Macitentan0.012371%
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