Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Pyoderma gangrenosum
ADR ID BADD_A03680
ADR Hierarchy
10      Immune system disorders
10.04      Autoimmune disorders
10.04.02      Skin autoimmune disorders NEC
10.04.02.009      Pyoderma gangrenosum
16      Neoplasms benign, malignant and unspecified (incl cysts and polyps)
16.32      Neoplasm related morbidities
16.32.03      Oncologic complications and emergencies
16.32.03.005      Pyoderma gangrenosum
23      Skin and subcutaneous tissue disorders
23.07      Skin and subcutaneous tissue disorders NEC
23.07.03      Skin and subcutaneous tissue ulcerations
23.07.03.001      Pyoderma gangrenosum
Description An idiopathic, rapidly evolving, and severely debilitating disease occurring most commonly in association with chronic ulcerative colitis. It is characterized by the presence of boggy, purplish ulcers with undermined borders, appearing mostly on the legs. The majority of cases are in people between 40 and 60 years old. Its etiology is unknown. [MeSH]
MedDRA Code 10037635
MeSH ID D017511
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Pyoderma gangenosum | Pyoderma gangrenosum | Pyoderma gangrenous | Pyoderma Gangrenosum
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00066Alendronic acid0.000044%
BADD_D00194Azacitidine0.000895%
BADD_D00195Azathioprine0.000627%
BADD_D00306Budesonide--
BADD_D00330Cabozantinib0.000302%
BADD_D00551Cyclosporine0.000243%
BADD_D00978Fulvestrant0.000334%
BADD_D01110Hydroxyurea0.000112%
BADD_D01119Ibrutinib0.000728%
BADD_D01120Ibuprofen--
BADD_D01136Imatinib0.000895%
BADD_D01168Interferon alfacon-1--
BADD_D01213Isotretinoin0.002830%
BADD_D01252Leflunomide0.000643%
BADD_D01285Levothyroxine0.000012%
BADD_D01397Mesalamine0.000366%
BADD_D01418Methotrexate--
BADD_D01433Methylprednisolone0.000032%
BADD_D01449Metronidazole--
BADD_D01687Pazopanib0.000224%
BADD_D01831Prednisolone0.000070%
BADD_D01834Prednisone0.000038%
BADD_D01933Ribavirin0.003956%
BADD_D02053Sofosbuvir0.000282%
BADD_D02100Sunitinib0.000168%
BADD_D02101Sunitinib malate--
BADD_D02192Thalidomide0.000241%
BADD_D02375Water--
BADD_D02407Upadacitinib0.000241%
BADD_D02498Abemaciclib0.000112%
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