Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Renal tubular necrosis
ADR ID BADD_A03770
ADR Hierarchy
20      Renal and urinary disorders
20.01      Renal disorders (excl nephropathies)
20.01.07      Renal vascular and ischaemic conditions
20.01.07.003      Renal tubular necrosis
Description Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure to toxic agents or renal ISCHEMIA following severe TRAUMA. [MeSH]
MedDRA Code 10038540
MeSH ID D007683
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Acute tubular necrosis | Kidney tubular necrosis | Kidney tubule necrosis | Lower nephron nephrosis | Necrosis kidney tubular | Necrosis tubular kidney | Nephrosis lower nephron | Renal tubular necrosis | Renal tubular necrosis acute | Tubular necrosis | Kidney Tubular Necrosis, Acute | Lower Nephron Nephrosis | Lower Nephron Nephroses | Nephron Nephroses, Lower | Nephron Nephrosis, Lower | Nephroses, Lower Nephron | Nephrosis, Lower Nephron | Acute Kidney Tubular Necrosis
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01971Rosuvastatin0.000068%
BADD_D02018Sildenafil0.000107%
BADD_D02026Simvastatin0.000025%
BADD_D02028Sirolimus--
BADD_D02029Sitagliptin0.000159%
BADD_D02037Sodium cation--
BADD_D02100Sunitinib0.000168%
BADD_D02105Tacrolimus0.004901%
BADD_D02154Tenofovir0.007755%
BADD_D02155Tenofovir disoproxil--
BADD_D02156Tenofovir disoproxil fumarate--
BADD_D02253Trabectedin0.000224%
BADD_D02270Tretinoin--
BADD_D02331Valsartan0.000053%
BADD_D02332Vancomycin--
BADD_D02344Vemurafenib0.000112%
BADD_D02348Verapamil0.000099%
BADD_D02369Voriconazole--
BADD_D02373Warfarin0.000070%
BADD_D02392Zoledronic acid0.030061%
BADD_D02394Zolpidem0.000025%
BADD_D02502Letermovir0.000423%
BADD_D02539Calcium0.000391%
BADD_D02560Iomeprol0.007113%
BADD_D02588Remdesivir0.000847%
BADD_D02617Cephalothin--
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