Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Retinal detachment
ADR ID BADD_A03845
ADR Hierarchy
06      Eye disorders
06.09      Ocular structural change, deposit and degeneration NEC
06.09.03      Retinal structural change, deposit and degeneration
06.09.03.003      Retinal detachment
12      Injury, poisoning and procedural complications
12.01      Injuries NEC
12.01.04      Eye injuries NEC
12.01.04.004      Retinal detachment
Description A disorder characterized by the separation of the inner retina layers from the underlying pigment epithelium. [CTCAE] Separation of the inner layers of the retina (neural retina) from the pigment epithelium. Retinal detachment occurs more commonly in men than in women, in eyes with degenerative myopia, in aging and in aphakia. It may occur after an uncomplicated cataract extraction, but it is seen more often if vitreous humor has been lost during surgery. (Dorland, 27th ed; Newell, Ophthalmology: Principles and Concepts, 7th ed, p310-12). [MeSH]
MedDRA Code 10038848
MeSH ID D012163
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Detached retina | Detachment retinal | Old retinal detachment, partial | Old retinal detachment, total or subtotal | Other forms of retinal detachment | Other forms of retinal detachment not elsewhere classified | Recent retinal detachment, partial, with giant tear | Recent retinal detachment, partial, with multiple defects | Recent retinal detachment, partial, with retinal dialysis | Recent retinal detachment, partial, with single defect | Recent retinal detachment, total or subtotal | Retinal detachment | Retinal detachment with retinal defect | Retinal detachment with retinal defect, unspecified | Retinal detachments and defects | Retinal detachments and defects, unspecified | Unspecified retinal detachment | Unspecified retinal detachments and defects | Vitreoretinal detachment | Amotio retinae | Extrafoveal localised retinal detachment | Extrafoveal localized retinal detachment | Subfoveal localised retinal detachment | Subfoveal localized retinal detachment | Macula-on retinal detachment | Macula-off retinal detachment | Neurosensory retinal detachment | Retinal Detachment | Detachment, Retinal | Detachments, Retinal | Retinal Detachments | Retinal Pigment Epithelial Detachment
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02480Alectinib0.000112%
BADD_D02483Ribociclib0.000112%
BADD_D02500Alpelisib0.000224%
BADD_D02504Lorlatinib0.000112%
BADD_D02506Erdafitinib0.000112%
BADD_D02509Brigatinib0.000112%
BADD_D02511Siponimod0.000362%
BADD_D02594Selumetinib0.000224%
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