Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Scleritis
ADR ID BADD_A03937
ADR Hierarchy
06      Eye disorders
06.04      Ocular infections, irritations and inflammations
06.04.07      Scleral infections, irritations and inflammations
06.04.07.002      Scleritis
10      Immune system disorders
10.02      Immune disorders NEC
10.02.01      Immune and associated conditions NEC
10.02.01.025      Scleritis
Description Refers to any inflammation of the sclera including episcleritis, a benign condition affecting only the episclera, which is generally short-lived and easily treated. Classic scleritis, on the other hand, affects deeper tissue and is characterized by higher rates of visual acuity loss and even mortality, particularly in necrotizing form. Its characteristic symptom is severe and general head pain. Scleritis has also been associated with systemic collagen disease. Etiology is unknown but is thought to involve a local immune response. Treatment is difficult and includes administration of anti-inflammatory and immunosuppressive agents such as corticosteroids. Inflammation of the sclera may also be secondary to inflammation of adjacent tissues, such as the conjunctiva. [MeSH]
MedDRA Code 10039705
MeSH ID D015423
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Anterior scleritis | Brawny scleritis | Other scleritis | Posterior scleritis | Scleritis | Scleritis and episcleritis | Scleritis NOS | Scleritis with corneal involvement | Scleritis, unspecified | Sclerouveitis | Scleritides | Episcleritis | Episcleritides | Necrotizing Scleritis | Necrotizing Scleritides | Scleritides, Necrotizing | Scleritis, Necrotizing
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00065Alendronate sodium--
BADD_D00066Alendronic acid0.000044%
BADD_D00284Bortezomib0.000112%
BADD_D00424Cevimeline--
BADD_D00425Cevimeline hydrochloride--
BADD_D00499Clomipramine--
BADD_D00500Clomipramine hydrochloride--
BADD_D00932Fluoxetine--
BADD_D00941Flurbiprofen--
BADD_D01117Ibandronic acid--
BADD_D01243Lamotrigine0.000055%
BADD_D01257Letrozole0.000263%
BADD_D01366Medroxyprogesterone acetate0.000119%
BADD_D01418Methotrexate0.000284%
BADD_D01478Mitomycin0.000280%
BADD_D01533Naproxen--
BADD_D01555Nepafenac0.000294%
BADD_D01662Pamidronic acid--
BADD_D01831Prednisolone0.000122%
BADD_D01834Prednisone0.000038%
BADD_D01835Pregabalin--
BADD_D01950Risedronic acid--
BADD_D02236Tofacitinib0.001206%
BADD_D02346Venlafaxine--
BADD_D02369Voriconazole--
BADD_D02375Water--
BADD_D02392Zoledronic acid0.038649%
BADD_D02394Zolpidem--
BADD_D02395Zolpidem tartrate--
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