Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Superior vena cava syndrome
ADR ID BADD_A04203
ADR Hierarchy
16      Neoplasms benign, malignant and unspecified (incl cysts and polyps)
16.32      Neoplasm related morbidities
16.32.03      Oncologic complications and emergencies
16.32.03.019      Superior vena cava syndrome
24      Vascular disorders
24.04      Arteriosclerosis, stenosis, vascular insufficiency and necrosis
24.04.09      Site specific necrosis and vascular insufficiency NEC
24.04.09.008      Superior vena cava syndrome
Description A disorder characterized by obstruction of the blood flow in the superior vena cava. Signs and symptoms include swelling and cyanosis of the face, neck, and upper arms, cough, orthopnea and headache. [CTCAE] A condition that occurs when the obstruction of the thin-walled SUPERIOR VENA CAVA interrupts blood flow from the head, upper extremities, and thorax to the RIGHT ATRIUM. Obstruction can be caused by NEOPLASMS; THROMBOSIS; ANEURYSM; or external compression. The syndrome is characterized by swelling and/or CYANOSIS of the face, neck, and upper arms. [MeSH]
MedDRA Code 10042569
MeSH ID D013479
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Superior vena cava syndrome | Superior vena cava compression | Superior Vena Cava Syndrome | Superior Vena Cava Obstruction | Superior Vena Cava Thrombosis
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00047Afatinib0.000112%
BADD_D00563Dabigatran0.000245%
BADD_D00800Erlotinib0.000112%
BADD_D00854Etoposide0.000280%
BADD_D01254Lenvatinib0.000112%
BADD_D01257Letrozole0.000263%
BADD_D01359Mechlorethamine--
BADD_D02373Warfarin0.000028%
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