Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Thrombotic microangiopathy
ADR ID BADD_A04286
ADR Hierarchy
01      Blood and lymphatic system disorders
01.01      Coagulopathies and bleeding diatheses (excl thrombocytopenic)
01.01.02      Coagulopathies
01.01.02.006      Thrombotic microangiopathy
20      Renal and urinary disorders
20.01      Renal disorders (excl nephropathies)
20.01.07      Renal vascular and ischaemic conditions
20.01.07.004      Thrombotic microangiopathy
24      Vascular disorders
24.01      Embolism and thrombosis
24.01.01      Non-site specific embolism and thrombosis
24.01.01.013      Thrombotic microangiopathy
Description Diseases that result in THROMBOSIS in MICROVASCULATURE. The two most prominent diseases are PURPURA, THROMBOTIC THROMBOCYTOPENIC; and HEMOLYTIC-UREMIC SYNDROME. Multiple etiological factors include VASCULAR ENDOTHELIAL CELL damage due to SHIGA TOXIN; FACTOR H deficiency; and aberrant VON WILLEBRAND FACTOR formation. [MeSH]
MedDRA Code 10043645
MeSH ID D057049
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Thrombotic microangiopathy | Thrombotic microangiopathy NOS | Thrombotic Microangiopathies | Microangiopathies, Thrombotic | Microangiopathy, Thrombotic | Thrombotic Microangiopathy
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01376Melphalan0.000112%
BADD_D01433Methylprednisolone0.000032%
BADD_D01478Mitomycin0.000112%
BADD_D01633Oxaliplatin0.000728%
BADD_D01653Paclitaxel0.000392%
BADD_D01687Pazopanib--
BADD_D01831Prednisolone0.000262%
BADD_D01834Prednisone0.000072%
BADD_D01888Quetiapine0.000055%
BADD_D01895Quinine0.029722%
BADD_D01933Ribavirin0.013845%
BADD_D01978Ruxolitinib0.000137%
BADD_D02028Sirolimus0.001675%
BADD_D02100Sunitinib0.000728%
BADD_D02101Sunitinib malate--
BADD_D02105Tacrolimus0.029555%
BADD_D02203Thiotepa0.000112%
BADD_D02324Valacyclovir hydrochloride--
BADD_D02329Valproic acid0.000150%
BADD_D02421Foscarnet0.000282%
BADD_D02473Sodium chloride--
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