Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Trismus
ADR ID BADD_A04394
ADR Hierarchy
15      Musculoskeletal and connective tissue disorders
15.05      Muscle disorders
15.05.04      Muscle tone abnormalities
15.05.04.004      Trismus
17      Nervous system disorders
17.01      Movement disorders (incl parkinsonism)
17.01.03      Dystonias
17.01.03.004      Trismus
Description A disorder characterized by lack of ability to open the mouth fully due to a decrease in the range of motion of the muscles of mastication. [CTCAE] Spasmodic contraction of the masseter muscle resulting in forceful jaw closure. This may be seen with a variety of diseases, including TETANUS, as a complication of radiation therapy, trauma, or in association with neoplastic conditions. [MeSH]
MedDRA Code 10044684
MeSH ID D014313
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Jaw cramp | Jaw movements disturbance | Jaw spasm | Lockjaw | Rigidity masticatory | Spasm temporomandibular | Trismus | Jaw spasticity | Restricted mouth opening | Lock Jaw | Masseter Muscle Spasm | Masseter Muscle Spasms | Muscle Spasm, Masseter | Muscle Spasms, Masseter | Spasm, Masseter Muscle | Spasms, Masseter Muscle | Masseter Spasm | Masseter Spasms | Spasm, Masseter | Spasms, Masseter
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00931Fluorouracil0.000276%
BADD_D00932Fluoxetine0.000059%
BADD_D00935Fluphenazine--
BADD_D00950Fluvoxamine--
BADD_D00951Fluvoxamine maleate--
BADD_D01003Ganciclovir--
BADD_D01054Haloperidol0.000376%
BADD_D01135Iloprost--
BADD_D01180Iohexol0.010670%
BADD_D01182Iopromide0.014227%
BADD_D01204Isoniazid0.002780%
BADD_D01222Ixabepilone--
BADD_D01243Lamotrigine0.000149%
BADD_D01265Levetiracetam0.000119%
BADD_D01275Levofloxacin0.000084%
BADD_D01330Lurasidone0.002558%
BADD_D01400Metaxalone0.000229%
BADD_D01431Methylphenidate0.000181%
BADD_D01442Metoclopramide0.000921%
BADD_D01449Metronidazole0.000026%
BADD_D01451Metyrosine--
BADD_D01498Morphine--
BADD_D01564Nicotine--
BADD_D01633Oxaliplatin0.001366%
BADD_D01653Paclitaxel0.000112%
BADD_D01656Paliperidone0.028958%
BADD_D01657Paliperidone palmitate--
BADD_D01679Paroxetine--
BADD_D01680Paroxetine hydrochloride--
BADD_D01681Paroxetine hydrochloride hemihydrate--
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